Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities

Ingeborg Grgurina, Mekki Bensaci, Gabriella Pocsfalvi, Luisa Mannina, Oscar Cruciani, Alberto Fiore, Vincenzo Fogliano, Kevin N. Sorensen, Jon Y. Takemoto*

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP508 differed from SP22 and other syringopeptins by having three instead of four α,β-unsaturated amino acids and a longer β-hydroxy acyl chain. Both SP508 and SP22 displayed growth-inhibitory activities against Mycobacterium smegmatis, other gram-positive bacteria, and yeasts but not against gram-negative bacteria. Structure-activity analyses of the SP508 and SP22 homologs indicated chemical structural features that lead to enhanced antimycobacterial activity by these pseudomonad cyclic lipodepsipeptides.

Original languageEnglish
Pages (from-to)5037-5045
Number of pages9
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number12
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

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Mycobacterium smegmatis
Pseudomonas syringae
Gram-Positive Bacteria
Malus
Gram-Negative Bacteria
Yeasts
Amino Acids
Growth
syringopeptin 508

Cite this

Grgurina, Ingeborg ; Bensaci, Mekki ; Pocsfalvi, Gabriella ; Mannina, Luisa ; Cruciani, Oscar ; Fiore, Alberto ; Fogliano, Vincenzo ; Sorensen, Kevin N. ; Takemoto, Jon Y. / Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities. In: Antimicrobial Agents and Chemotherapy. 2005 ; Vol. 49, No. 12. pp. 5037-5045.
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author = "Ingeborg Grgurina and Mekki Bensaci and Gabriella Pocsfalvi and Luisa Mannina and Oscar Cruciani and Alberto Fiore and Vincenzo Fogliano and Sorensen, {Kevin N.} and Takemoto, {Jon Y.}",
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Grgurina, I, Bensaci, M, Pocsfalvi, G, Mannina, L, Cruciani, O, Fiore, A, Fogliano, V, Sorensen, KN & Takemoto, JY 2005, 'Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities', Antimicrobial Agents and Chemotherapy, vol. 49, no. 12, pp. 5037-5045. https://doi.org/10.1128/AAC.49.12.5037-5045.2005

Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities. / Grgurina, Ingeborg; Bensaci, Mekki; Pocsfalvi, Gabriella; Mannina, Luisa; Cruciani, Oscar; Fiore, Alberto; Fogliano, Vincenzo; Sorensen, Kevin N.; Takemoto, Jon Y.

In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 12, 12.2005, p. 5037-5045.

Research output: Contribution to journalArticle

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AU - Grgurina, Ingeborg

AU - Bensaci, Mekki

AU - Pocsfalvi, Gabriella

AU - Mannina, Luisa

AU - Cruciani, Oscar

AU - Fiore, Alberto

AU - Fogliano, Vincenzo

AU - Sorensen, Kevin N.

AU - Takemoto, Jon Y.

PY - 2005/12

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AB - The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP508 differed from SP22 and other syringopeptins by having three instead of four α,β-unsaturated amino acids and a longer β-hydroxy acyl chain. Both SP508 and SP22 displayed growth-inhibitory activities against Mycobacterium smegmatis, other gram-positive bacteria, and yeasts but not against gram-negative bacteria. Structure-activity analyses of the SP508 and SP22 homologs indicated chemical structural features that lead to enhanced antimycobacterial activity by these pseudomonad cyclic lipodepsipeptides.

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