Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities

Ingeborg Grgurina, Mekki Bensaci, Gabriella Pocsfalvi, Luisa Mannina, Oscar Cruciani, Alberto Fiore, Vincenzo Fogliano, Kevin N. Sorensen, Jon Y. Takemoto*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


The syringopeptins are a group of antimicrobial cyclic lipodepsipeptides produced by several plant-associated pseudomonads. A novel syringopeptin, SP508, was shown to be produced as two homologs (A and B) by Pseudomonas syringae pv. lachrymans strain 508 from apple and to structurally resemble syringopeptin SP22. SP508 differed from SP22 and other syringopeptins by having three instead of four α,β-unsaturated amino acids and a longer β-hydroxy acyl chain. Both SP508 and SP22 displayed growth-inhibitory activities against Mycobacterium smegmatis, other gram-positive bacteria, and yeasts but not against gram-negative bacteria. Structure-activity analyses of the SP508 and SP22 homologs indicated chemical structural features that lead to enhanced antimycobacterial activity by these pseudomonad cyclic lipodepsipeptides.

Original languageEnglish
Pages (from-to)5037-5045
Number of pages9
JournalAntimicrobial Agents and Chemotherapy
Issue number12
Publication statusPublished - Dec 2005
Externally publishedYes


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