Oral treatment with gallic acid and quercetin alleviates lindaneinduced cardiotoxicity in rats

Viswanadha Vijaya Padma, Paramasivan Poornima, Chermakani Prakash, Ramachandran Bhavani

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Lindane is a man-made organochlorine pesticide used for agricultural purposes. Since lindane-induced toxicity is mediated by free radical generation, this investigation was carried out to study the protective effects of gallic acid and quercetin against lindane-induced cardiotoxicity. Lindane (100 mg·(kg body mass)-1) was administered orally to rats for 30 days. Histological analysis revealed pathological changes in the heart of lindane-treated rats. Biochemical analysis of the lindane-treated animals showed elevated activity for serum marker enzymes, lipid peroxidation (LPO), and membrane-bound Ca2+ ATPase, with a concomitant decrease in the level of non-enzymic antioxidant (GSH), enzymic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase (GPx), and glutathione-S-transferase (GST), and membrane-bound ATPases like Na+/K+ ATPase and Mg2+ ATPase in heart tissue. The results suggest that gallic acid and quercetin offer protection against lindane-induced myocardial damage, possibly through maintaining levels of endogenous antioxidant enzymes and membrane bound ATPase activity, as well as inhibiting lipid peroxidation.

Original languageEnglish
Pages (from-to)134-140
Number of pages7
JournalCanadian Journal of Physiology and Pharmacology
Volume91
Issue number2
Early online date15 Nov 2012
DOIs
Publication statusPublished - 1 Feb 2013
Externally publishedYes

Fingerprint

Lindane
Gallic Acid
Quercetin
Antioxidants
Therapeutics
Lipid Peroxidation
Membranes
Adenosine Triphosphatases
Ca(2+) Mg(2+)-ATPase
Calcium-Transporting ATPases
Enzymes
Glutathione Peroxidase
Cardiotoxicity
Glutathione Transferase
Pesticides
Catalase
Superoxide Dismutase
Free Radicals
Biomarkers

Cite this

Padma, Viswanadha Vijaya ; Poornima, Paramasivan ; Prakash, Chermakani ; Bhavani, Ramachandran. / Oral treatment with gallic acid and quercetin alleviates lindaneinduced cardiotoxicity in rats. In: Canadian Journal of Physiology and Pharmacology. 2013 ; Vol. 91, No. 2. pp. 134-140.
@article{7ce4ad621250486484ebdca297e0e53c,
title = "Oral treatment with gallic acid and quercetin alleviates lindaneinduced cardiotoxicity in rats",
abstract = "Lindane is a man-made organochlorine pesticide used for agricultural purposes. Since lindane-induced toxicity is mediated by free radical generation, this investigation was carried out to study the protective effects of gallic acid and quercetin against lindane-induced cardiotoxicity. Lindane (100 mg·(kg body mass)-1) was administered orally to rats for 30 days. Histological analysis revealed pathological changes in the heart of lindane-treated rats. Biochemical analysis of the lindane-treated animals showed elevated activity for serum marker enzymes, lipid peroxidation (LPO), and membrane-bound Ca2+ ATPase, with a concomitant decrease in the level of non-enzymic antioxidant (GSH), enzymic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase (GPx), and glutathione-S-transferase (GST), and membrane-bound ATPases like Na+/K+ ATPase and Mg2+ ATPase in heart tissue. The results suggest that gallic acid and quercetin offer protection against lindane-induced myocardial damage, possibly through maintaining levels of endogenous antioxidant enzymes and membrane bound ATPase activity, as well as inhibiting lipid peroxidation.",
author = "Padma, {Viswanadha Vijaya} and Paramasivan Poornima and Chermakani Prakash and Ramachandran Bhavani",
year = "2013",
month = "2",
day = "1",
doi = "10.1139/cjpp-2012-0279",
language = "English",
volume = "91",
pages = "134--140",
journal = "Canadian Journal of Physiology and Pharmacology",
issn = "0008-4212",
publisher = "National Research Council of Canada",
number = "2",

}

Oral treatment with gallic acid and quercetin alleviates lindaneinduced cardiotoxicity in rats. / Padma, Viswanadha Vijaya; Poornima, Paramasivan; Prakash, Chermakani; Bhavani, Ramachandran.

In: Canadian Journal of Physiology and Pharmacology, Vol. 91, No. 2, 01.02.2013, p. 134-140.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oral treatment with gallic acid and quercetin alleviates lindaneinduced cardiotoxicity in rats

AU - Padma, Viswanadha Vijaya

AU - Poornima, Paramasivan

AU - Prakash, Chermakani

AU - Bhavani, Ramachandran

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Lindane is a man-made organochlorine pesticide used for agricultural purposes. Since lindane-induced toxicity is mediated by free radical generation, this investigation was carried out to study the protective effects of gallic acid and quercetin against lindane-induced cardiotoxicity. Lindane (100 mg·(kg body mass)-1) was administered orally to rats for 30 days. Histological analysis revealed pathological changes in the heart of lindane-treated rats. Biochemical analysis of the lindane-treated animals showed elevated activity for serum marker enzymes, lipid peroxidation (LPO), and membrane-bound Ca2+ ATPase, with a concomitant decrease in the level of non-enzymic antioxidant (GSH), enzymic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase (GPx), and glutathione-S-transferase (GST), and membrane-bound ATPases like Na+/K+ ATPase and Mg2+ ATPase in heart tissue. The results suggest that gallic acid and quercetin offer protection against lindane-induced myocardial damage, possibly through maintaining levels of endogenous antioxidant enzymes and membrane bound ATPase activity, as well as inhibiting lipid peroxidation.

AB - Lindane is a man-made organochlorine pesticide used for agricultural purposes. Since lindane-induced toxicity is mediated by free radical generation, this investigation was carried out to study the protective effects of gallic acid and quercetin against lindane-induced cardiotoxicity. Lindane (100 mg·(kg body mass)-1) was administered orally to rats for 30 days. Histological analysis revealed pathological changes in the heart of lindane-treated rats. Biochemical analysis of the lindane-treated animals showed elevated activity for serum marker enzymes, lipid peroxidation (LPO), and membrane-bound Ca2+ ATPase, with a concomitant decrease in the level of non-enzymic antioxidant (GSH), enzymic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase (GPx), and glutathione-S-transferase (GST), and membrane-bound ATPases like Na+/K+ ATPase and Mg2+ ATPase in heart tissue. The results suggest that gallic acid and quercetin offer protection against lindane-induced myocardial damage, possibly through maintaining levels of endogenous antioxidant enzymes and membrane bound ATPase activity, as well as inhibiting lipid peroxidation.

U2 - 10.1139/cjpp-2012-0279

DO - 10.1139/cjpp-2012-0279

M3 - Article

C2 - 23458197

AN - SCOPUS:84874632194

VL - 91

SP - 134

EP - 140

JO - Canadian Journal of Physiology and Pharmacology

JF - Canadian Journal of Physiology and Pharmacology

SN - 0008-4212

IS - 2

ER -