Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 13523-13534 |
| Number of pages | 12 |
| Journal | Environmental Science and Technology |
| Volume | 52 |
| Issue number | 22 |
| Early online date | 19 Oct 2018 |
| DOIs | |
| Publication status | Published - 20 Nov 2018 |
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Persistent organic pollutant burden, experimental POP exposure and tissue properties affect metabolic profiles of blubber from grey seal pups. / Robinson, Kelly J.; Hall, Ailsa; Debier, Cathy; Eppe, Gauthier; Jaspart, Jean-Pierre; Bennett, Kimberley A. .
In: Environmental Science and Technology, Vol. 52, No. 22, 20.11.2018, p. 13523-13534.Research output: Contribution to journal › Article
TY - JOUR
T1 - Persistent organic pollutant burden, experimental POP exposure and tissue properties affect metabolic profiles of blubber from grey seal pups
AU - Robinson, Kelly J.
AU - Hall, Ailsa
AU - Debier, Cathy
AU - Eppe, Gauthier
AU - Jaspart, Jean-Pierre
AU - Bennett, Kimberley A.
PY - 2018/11/20
Y1 - 2018/11/20
N2 - Persistent organic pollutants (POPs) are toxic, ubiquitous, resist breakdown, bioaccumulate in living tissue and biomagnify in food webs. POPs can also alter energy balance in humans and wildlife. Marine mammals experience high POP concentrations, but consequences for their tissue metabolic characteristics are unknown. We used blubber explants from wild, grey seal (Halichoerus grypus) pups to examine impacts of intrinsic tissue POP burden and acute experimental POP exposure on adipose metabolic characteristics. Glucose use, lactate production and lipolytic rate differed between matched inner and outer blubber explants from the same individuals and between feeding and natural fasting. Glucose use decreased with blubber dioxin-like PCBs (DL-PCB) and increased with acute experimental POP exposure. Lactate production increased with DL-PCBs during feeding, but decreased with DL-PCBs during fasting. Lipolytic rate increased with blubber dichlorodiphenyltrichloroethane (DDT) and its metabolites (DDX) in fasting animals, but declined with DDX when animals were feeding. Our data show that POP burdens are high enough in seal pups to alter adipose function early in life, when fat deposition and mobilisation are vital. Such POP-induced alterations to adipose glucose use may significantly alter energy balance regulation in marine top predators with the potential for long term impacts on fitness and survival.
AB - Persistent organic pollutants (POPs) are toxic, ubiquitous, resist breakdown, bioaccumulate in living tissue and biomagnify in food webs. POPs can also alter energy balance in humans and wildlife. Marine mammals experience high POP concentrations, but consequences for their tissue metabolic characteristics are unknown. We used blubber explants from wild, grey seal (Halichoerus grypus) pups to examine impacts of intrinsic tissue POP burden and acute experimental POP exposure on adipose metabolic characteristics. Glucose use, lactate production and lipolytic rate differed between matched inner and outer blubber explants from the same individuals and between feeding and natural fasting. Glucose use decreased with blubber dioxin-like PCBs (DL-PCB) and increased with acute experimental POP exposure. Lactate production increased with DL-PCBs during feeding, but decreased with DL-PCBs during fasting. Lipolytic rate increased with blubber dichlorodiphenyltrichloroethane (DDT) and its metabolites (DDX) in fasting animals, but declined with DDX when animals were feeding. Our data show that POP burdens are high enough in seal pups to alter adipose function early in life, when fat deposition and mobilisation are vital. Such POP-induced alterations to adipose glucose use may significantly alter energy balance regulation in marine top predators with the potential for long term impacts on fitness and survival.
U2 - 10.1021/acs.est.8b04240
DO - 10.1021/acs.est.8b04240
M3 - Article
VL - 52
SP - 13523
EP - 13534
JO - Environmental Science and Technology
JF - Environmental Science and Technology
IS - 22
ER -