Persistent organic pollutant burden, experimental POP exposure and tissue properties affect metabolic profiles of blubber from grey seal pups

Kelly J. Robinson, Ailsa Hall, Cathy Debier, Gauthier Eppe, Jean-Pierre Jaspart, Kimberley A. Bennett

Research output: Contribution to journalArticle

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Abstract

Persistent organic pollutants (POPs) are toxic, ubiquitous, resist breakdown, bioaccumulate in living tissue and biomagnify in food webs. POPs can also alter energy balance in humans and wildlife. Marine mammals experience high POP concentrations, but consequences for their tissue metabolic characteristics are unknown. We used blubber explants from wild, grey seal (Halichoerus grypus) pups to examine impacts of intrinsic tissue POP burden and acute experimental POP exposure on adipose metabolic characteristics. Glucose use, lactate production and lipolytic rate differed between matched inner and outer blubber explants from the same individuals and between feeding and natural fasting. Glucose use decreased with blubber dioxin-like PCBs (DL-PCB) and increased with acute experimental POP exposure. Lactate production increased with DL-PCBs during feeding, but decreased with DL-PCBs during fasting. Lipolytic rate increased with blubber dichlorodiphenyltrichloroethane (DDT) and its metabolites (DDX) in fasting animals, but declined with DDX when animals were feeding. Our data show that POP burdens are high enough in seal pups to alter adipose function early in life, when fat deposition and mobilisation are vital. Such POP-induced alterations to adipose glucose use may significantly alter energy balance regulation in marine top predators with the potential for long term impacts on fitness and survival.
Original languageEnglish
Pages (from-to)13523-13534
Number of pages12
JournalEnvironmental Science and Technology
Volume52
Issue number22
Early online date19 Oct 2018
DOIs
Publication statusPublished - 20 Nov 2018

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fasting
PCB
glucose
energy balance
persistent organic pollutant
pollutant exposure
tissue
animal
marine mammal
DDT
dioxin
fat
mobilization
food web
metabolite
fitness
predator
rate

Cite this

Robinson, Kelly J. ; Hall, Ailsa ; Debier, Cathy ; Eppe, Gauthier ; Jaspart, Jean-Pierre ; Bennett, Kimberley A. . / Persistent organic pollutant burden, experimental POP exposure and tissue properties affect metabolic profiles of blubber from grey seal pups. In: Environmental Science and Technology. 2018 ; Vol. 52, No. 22. pp. 13523-13534.
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Persistent organic pollutant burden, experimental POP exposure and tissue properties affect metabolic profiles of blubber from grey seal pups. / Robinson, Kelly J.; Hall, Ailsa; Debier, Cathy; Eppe, Gauthier; Jaspart, Jean-Pierre; Bennett, Kimberley A. .

In: Environmental Science and Technology, Vol. 52, No. 22, 20.11.2018, p. 13523-13534.

Research output: Contribution to journalArticle

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AU - Robinson, Kelly J.

AU - Hall, Ailsa

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AB - Persistent organic pollutants (POPs) are toxic, ubiquitous, resist breakdown, bioaccumulate in living tissue and biomagnify in food webs. POPs can also alter energy balance in humans and wildlife. Marine mammals experience high POP concentrations, but consequences for their tissue metabolic characteristics are unknown. We used blubber explants from wild, grey seal (Halichoerus grypus) pups to examine impacts of intrinsic tissue POP burden and acute experimental POP exposure on adipose metabolic characteristics. Glucose use, lactate production and lipolytic rate differed between matched inner and outer blubber explants from the same individuals and between feeding and natural fasting. Glucose use decreased with blubber dioxin-like PCBs (DL-PCB) and increased with acute experimental POP exposure. Lactate production increased with DL-PCBs during feeding, but decreased with DL-PCBs during fasting. Lipolytic rate increased with blubber dichlorodiphenyltrichloroethane (DDT) and its metabolites (DDX) in fasting animals, but declined with DDX when animals were feeding. Our data show that POP burdens are high enough in seal pups to alter adipose function early in life, when fat deposition and mobilisation are vital. Such POP-induced alterations to adipose glucose use may significantly alter energy balance regulation in marine top predators with the potential for long term impacts on fitness and survival.

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