Platelet membrane biomimetic bufalin-loaded hollow MnO2 nanoparticles for MRI-guided chemo-chemodynamic combined therapy of cancer

Haijun Wang, David H. Bremner, Kunhua Wu, Xiarong Gong, Qing Fan, Xiaotian Xie, Hongmei Zhang, Junzi Wu, Li-Min Zhu*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    In this study, platelet membrane (PLTM) biomimetic hollow MnO2 nanoparticles were prepared and these were investigated for delivery of bufalin. Additionally, these nanoparticles, in response to the tumor microenvironment, showed rapid drug release and generated the hydroxyl radicals (HO•) by the Fenton reaction between Mn2+ and endogenous H2O2 for use in MRI-guided anti-tumor activity. Firstly, poly(lactic-co-glycolic acid) (PLGA) nanoparticles were used to reduce KMnO4 to HMnO2 nanoparticles followed by acetone etching. After bufalin loading, these NPs were biomimetically cloaked with PLTM to form PLTM-HMnO2@Bu NPs. In vitro release profiles showed that the NPs responded to acid pH and glutathione (GSH) to induce decomposition of MnO2, resulting in rapid release of bufalin and yielding the MRI contrast agent Mn2+. In vivo MRI studies revealed an obvious T1 contrast enhancement at the tumor site because of a combination of the EPR and active targeting effects. The PLTM-HMnO2 NPs led to effective inhibition of tumor growth, attributing to Fenton-like Mn2+ conversion of endogenous H2O2 in the tumor to highly toxic HO• and this anti-tumor efficacy was enhanced when combined with chemotherapy. These results indicate that the PLTM biomimetic HMnO2 nanoparticles are promising drug delivery systems for MRI-monitoring and enhanced targeted treatment of tumors.
    Original languageEnglish
    Article number122848
    Number of pages15
    JournalChemical Engineering Journal
    Volume382
    Early online date16 Sep 2019
    DOIs
    Publication statusPublished - 15 Feb 2020

    Fingerprint Dive into the research topics of 'Platelet membrane biomimetic bufalin-loaded hollow MnO<sub>2</sub> nanoparticles for MRI-guided chemo-chemodynamic combined therapy of cancer'. Together they form a unique fingerprint.

  • Cite this