One of the greatest challenges in joint arthroplasty is to enhance the wear resistance of ultrahigh molecular weight polyethylene (UHMWPE), which is one of the most successful polymers as acetabular bearings for total hip joint prosthesis. In order to improve UHMWPE wear rates, it is necessary to develop efficient methods to predict its wear rates in various conditions and therefore help in improving its wear resistance, mechanical properties, and increasing its life span inside the body. This article presents a support vector machine using a grey wolf optimizer (SVM-GWO) hybrid regression model to predict the wear rates of UHMWPE based on published polyethylene data from pin on disc (PoD) wear experiments typically performed in the field of prosthetic hip implants. The dataset was an aggregate of 29 different PoD UHMWPE datasets collected from Google Scholar and PubMed databases, and it consisted of 129 data points. Shapley additive explanations (SHAP) values were used to interpret the presented model to identify the most important and decisive parameters that affect the wear rates of UHMWPE and, therefore, predict its wear behavior inside the body under different conditions. The results revealed that radiation doses had the highest impact on the model’s prediction, where high values of radiation doses had a negative impact on the model output. The pronounced effect of irradiation doses and surface roughness on the wear rates of polyethylene was clear in the results when average disc surface roughness (Ra) values were below 0.05 μm, and irradiation doses were above 95 kGy produced 0 mg/MC wear rate. The proposed model proved to be a reliable and robust model for the prediction of wear rates and prioritizing factors that most significantly affect its wear rates. The proposed model can help material engineers to further design polyethylene acetabular linings via improving the wear resistance and minimizing the necessity for wear experiments.