Repair, abort, ignore? Strategies for dealing with UV damage

Hemanth Tummala, Hilal S. Khalil, Nikolai Zhelev

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)
    55 Downloads (Pure)

    Abstract

    DNA repair is a prominent member of the nuclear transactions triad (replication, transcription, and repair). Sophisticated mechanisms govern the cellular process of decision-making (to repair or not to repair, to proceed with cell cycle or not and, eventually, to let the cell survive or die) and the temporal and spatial distribution of the DNA repair activities. UV radiation is a very common and virtually unavoidable mutagen whose carcinogenic potential seems to accumulate over time. Various strategies have been developed to avoid or decrease UV damage to cellular DNA, based on prevention of exposure as well as on post-irradiation measures. It is, however, important to acknowledge that the individual capacity for DNA repair varies during the life of the individual and must, therefore, be assessed so as to determine whether the individual is coping with environmental UV damage. Assessment of individual repair capacity might greatly modify the existing therapeutic strategies for common cancers and ought to become a routine part of health prophylaxis.
    Original languageEnglish
    Pages (from-to)2443-2446
    Number of pages4
    JournalBiotechnology and Biotechnological Equipment
    Volume25
    Issue number3
    DOIs
    Publication statusPublished - Aug 2011

    Keywords

    • UV
    • DNA damage
    • DNA repair
    • Individual repair capacity

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