Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

Victor V. Revin; Natalia V. Gromova; Elvira S. Revina; Maria I. Martynova; Angelina I. Seikina; Nadezhda V. Revina; Oksana G. Imarova; Ilia N. Solomadin; Alexander Yu. Tychkov; Nikolai Zhelev

doi:10.1155/2016/3429604

Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

Victor V. Revin, Natalia V. Gromova, Elvira S. Revina, Maria I. Martynova, Angelina I. Seikina, Nadezhda V. Revina, Oksana G. Imarova, Ilia N. Solomadin, Alexander Yu. Tychkov, Nikolai Zhelev

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Abstract

The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover themorphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes’ hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.

Original language	English
Article number	3429604
Number of pages	11
Journal	BioMed Research International
Volume	2016
DOIs	https://doi.org/10.1155/2016/3429604
Publication status	Published - 4 Oct 2016

Keywords

Ischemic heart disease
Stable angina
Arterial hypertension
Erythrocyte
Phospholipids of biomembranes
Hematoporphyrin of hemoglobin
RAMAN spectroscopy
Laser interference microscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Zhelev_RoleOfMembraneLipids_Published_2016Final published version, 5.06 MBLicence: CC BY

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title = "Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases",

abstract = "The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover themorphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes{\textquoteright} hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.",

author = "Revin, {Victor V.} and Gromova, {Natalia V.} and Revina, {Elvira S.} and Martynova, {Maria I.} and Seikina, {Angelina I.} and Revina, {Nadezhda V.} and Imarova, {Oksana G.} and Solomadin, {Ilia N.} and Tychkov, {Alexander Yu.} and Nikolai Zhelev",

year = "2016",

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doi = "10.1155/2016/3429604",

language = "English",

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T1 - Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

AU - Revin, Victor V.

AU - Gromova, Natalia V.

AU - Revina, Elvira S.

AU - Martynova, Maria I.

AU - Seikina, Angelina I.

AU - Revina, Nadezhda V.

AU - Imarova, Oksana G.

AU - Solomadin, Ilia N.

AU - Tychkov, Alexander Yu.

AU - Zhelev, Nikolai

PY - 2016/10/4

Y1 - 2016/10/4

N2 - The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover themorphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes’ hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.

AB - The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover themorphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes’ hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.

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DO - 10.1155/2016/3429604

M3 - Article

VL - 2016

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 3429604

ER -

Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

Abstract

Keywords

UN SDGs

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