Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

Victor V. Revin, Natalia V. Gromova, Elvira S. Revina, Maria I. Martynova, Angelina I. Seikina, Nadezhda V. Revina, Oksana G. Imarova, Ilia N. Solomadin, Alexander Yu. Tychkov, Nikolai Zhelev

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    Abstract

    The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover themorphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes’ hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.
    Original languageEnglish
    Article number3429604
    Number of pages11
    JournalBioMed Research International
    Volume2016
    DOIs
    Publication statusPublished - 4 Oct 2016

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    Membrane Lipids
    Hemoglobins
    Cardiovascular Diseases
    Erythrocytes
    Interference Microscopy
    Oxygen
    Raman spectroscopy
    Raman Spectrum Analysis
    Microscopic examination
    Confocal Microscopy
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Lasers
    Chemical analysis
    Medicine
    Phospholipids
    Erythrocyte Membrane
    Fatty Acids
    Tissue
    Calcium
    Membranes

    Cite this

    Revin, V. V., Gromova, N. V., Revina, E. S., Martynova, M. I., Seikina, A. I., Revina, N. V., ... Zhelev, N. (2016). Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases. BioMed Research International, 2016, [3429604]. https://doi.org/10.1155/2016/3429604
    Revin, Victor V. ; Gromova, Natalia V. ; Revina, Elvira S. ; Martynova, Maria I. ; Seikina, Angelina I. ; Revina, Nadezhda V. ; Imarova, Oksana G. ; Solomadin, Ilia N. ; Tychkov, Alexander Yu. ; Zhelev, Nikolai. / Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases. In: BioMed Research International. 2016 ; Vol. 2016.
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    abstract = "The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover themorphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes’ hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.",
    author = "Revin, {Victor V.} and Gromova, {Natalia V.} and Revina, {Elvira S.} and Martynova, {Maria I.} and Seikina, {Angelina I.} and Revina, {Nadezhda V.} and Imarova, {Oksana G.} and Solomadin, {Ilia N.} and Tychkov, {Alexander Yu.} and Nikolai Zhelev",
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    Revin, VV, Gromova, NV, Revina, ES, Martynova, MI, Seikina, AI, Revina, NV, Imarova, OG, Solomadin, IN, Tychkov, AY & Zhelev, N 2016, 'Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases', BioMed Research International, vol. 2016, 3429604. https://doi.org/10.1155/2016/3429604

    Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases. / Revin, Victor V.; Gromova, Natalia V.; Revina, Elvira S.; Martynova, Maria I.; Seikina, Angelina I.; Revina, Nadezhda V.; Imarova, Oksana G.; Solomadin, Ilia N.; Tychkov, Alexander Yu.; Zhelev, Nikolai.

    In: BioMed Research International, Vol. 2016, 3429604, 04.10.2016.

    Research output: Contribution to journalArticle

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    AU - Revin, Victor V.

    AU - Gromova, Natalia V.

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    AU - Martynova, Maria I.

    AU - Seikina, Angelina I.

    AU - Revina, Nadezhda V.

    AU - Imarova, Oksana G.

    AU - Solomadin, Ilia N.

    AU - Tychkov, Alexander Yu.

    AU - Zhelev, Nikolai

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    AB - The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover themorphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes’ hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.

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