Abstract
| Original language | English |
|---|---|
| Article number | 3429604 |
| Number of pages | 11 |
| Journal | BioMed Research International |
| Volume | 2016 |
| DOIs | |
| Publication status | Published - 4 Oct 2016 |
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Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases. / Revin, Victor V.; Gromova, Natalia V.; Revina, Elvira S.; Martynova, Maria I.; Seikina, Angelina I.; Revina, Nadezhda V.; Imarova, Oksana G.; Solomadin, Ilia N.; Tychkov, Alexander Yu.; Zhelev, Nikolai.
In: BioMed Research International, Vol. 2016, 3429604, 04.10.2016.Research output: Contribution to journal › Article
TY - JOUR
T1 - Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases
AU - Revin, Victor V.
AU - Gromova, Natalia V.
AU - Revina, Elvira S.
AU - Martynova, Maria I.
AU - Seikina, Angelina I.
AU - Revina, Nadezhda V.
AU - Imarova, Oksana G.
AU - Solomadin, Ilia N.
AU - Tychkov, Alexander Yu.
AU - Zhelev, Nikolai
PY - 2016/10/4
Y1 - 2016/10/4
N2 - The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover themorphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes’ hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.
AB - The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover themorphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes’ hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.
U2 - 10.1155/2016/3429604
DO - 10.1155/2016/3429604
M3 - Article
VL - 2016
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
M1 - 3429604
ER -