Single-cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success

S. G. Brown*, M.C. Kelly, S. Costello, S.J. Publicover, C.L.R. Barratt, S.M. Martins da Silva

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Background: Progesterone (P4) influences human sperm function by stimulating an elevation of intracellular calcium concentration [Ca2+]i. Assessment of the P4 response in sperm populations indicates an association between poor [Ca2+]i increase and reduced fertilisation capacity. Analysis of P4 sensitivity single donor sperm demonstrates heterogeneity in responsiveness and dynamics of [Ca2+]i increase.
Original languageEnglish
Title of host publicationXIIIth International Symposium on Spermatology
EditorsLars Björndahl, John Flanagan, Rebecka Holmberg, Ulrik Kvist
Place of PublicationCham
Number of pages2
ISBN (Electronic)9783030662929
ISBN (Print)9783030662912
Publication statusPublished - 27 Jul 2021

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