Single-cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success

S. G. Brown; M.C. Kelly; S. Costello; S.J. Publicover; C.L.R. Barratt; S.M. Martins da Silva

doi:10.1007/978-3-030-66292-9_45

Single-cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success

S. G. Brown^*, M.C. Kelly, S. Costello, S.J. Publicover, C.L.R. Barratt, S.M. Martins da Silva

^*Corresponding author for this work

SAS - HSC - Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Background: Progesterone (P4) influences human sperm function by stimulating an elevation of intracellular calcium concentration [Ca2+]i. Assessment of the P4 response in sperm populations indicates an association between poor [Ca2+]i increase and reduced fertilisation capacity. Analysis of P4 sensitivity single donor sperm demonstrates heterogeneity in responsiveness and dynamics of [Ca2+]i increase.

Original language	English
Title of host publication	XIIIth International Symposium on Spermatology
Editors	Lars Björndahl, John Flanagan, Rebecka Holmberg, Ulrik Kvist
Place of Publication	Cham
Publisher	Springer
Pages	339-340
Number of pages	2
ISBN (Electronic)	9783030662929
ISBN (Print)	9783030662912
DOIs	https://doi.org/10.1007/978-3-030-66292-9_45
Publication status	Published - 27 Jul 2021

Access to Document

10.1007/978-3-030-66292-9_45

Cite this

Brown, S. G., Kelly, M. C., Costello, S., Publicover, S. J., Barratt, C. L. R., & Martins da Silva, S. M. (2021). Single-cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success. In L. Björndahl, J. Flanagan, R. Holmberg, & U. Kvist (Eds.), XIIIth International Symposium on Spermatology (pp. 339-340). Springer. https://doi.org/10.1007/978-3-030-66292-9_45

Brown, S. G. ; Kelly, M.C. ; Costello, S. ; Publicover, S.J. ; Barratt, C.L.R. ; Martins da Silva, S.M. / Single-cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success. XIIIth International Symposium on Spermatology. editor / Lars Björndahl ; John Flanagan ; Rebecka Holmberg ; Ulrik Kvist. Cham : Springer, 2021. pp. 339-340

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Brown, SG, Kelly, MC, Costello, S, Publicover, SJ, Barratt, CLR & Martins da Silva, SM 2021, Single-cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success. in L Björndahl, J Flanagan, R Holmberg & U Kvist (eds), XIIIth International Symposium on Spermatology. Springer, Cham, pp. 339-340. https://doi.org/10.1007/978-3-030-66292-9_45

Single-cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success. / Brown, S. G.; Kelly, M.C.; Costello, S.; Publicover, S.J.; Barratt, C.L.R.; Martins da Silva, S.M.

XIIIth International Symposium on Spermatology. ed. / Lars Björndahl; John Flanagan; Rebecka Holmberg; Ulrik Kvist. Cham : Springer, 2021. p. 339-340.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - Background: Progesterone (P4) influences human sperm function by stimulating an elevation of intracellular calcium concentration [Ca2+]i. Assessment of the P4 response in sperm populations indicates an association between poor [Ca2+]i increase and reduced fertilisation capacity. Analysis of P4 sensitivity single donor sperm demonstrates heterogeneity in responsiveness and dynamics of [Ca2+]i increase.

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Brown SG, Kelly MC, Costello S, Publicover SJ, Barratt CLR, Martins da Silva SM. Single-cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success. In Björndahl L, Flanagan J, Holmberg R, Kvist U, editors, XIIIth International Symposium on Spermatology. Cham: Springer. 2021. p. 339-340 https://doi.org/10.1007/978-3-030-66292-9_45