Abstract
TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.
| Original language | English |
|---|---|
| Pages (from-to) | 9176-9179 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 48 |
| Issue number | 48 |
| Early online date | 26 Oct 2009 |
| DOIs | |
| Publication status | Published - 16 Nov 2009 |
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Cite this
Fyfe, P. K., Rao, V. A., Zemla, A., Cameron, S., & Hunter, W. N. (2009). Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide. Angewandte Chemie - International Edition, 48(48), 9176-9179. https://doi.org/10.1002/anie.200903407