Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Paul K. Fyfe, Vincenzo A. Rao, Aleksandra Zemla, Scott Cameron, William N. Hunter

    Research output: Contribution to journal › Article

    41 Citations (Scopus)

    Abstract

    TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.

    Original languageEnglish
    Pages (from-to)9176-9179
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume48
    Issue number48
    Early online date26 Oct 2009
    DOIs
    Publication statusPublished - 16 Nov 2009

    Fingerprint

    Nicotinamidase
    Pyrazinamide
    Niacin
    Crystal structure
    Chemical activation
    Acids
    Enzymes
    Pharmaceutical Preparations
    pyrazinoic acid

    Cite this

    Fyfe, Paul K. ; Rao, Vincenzo A. ; Zemla, Aleksandra ; Cameron, Scott ; Hunter, William N. / Specificity and mechanism of Acinetobacter baumanii nicotinamidase : implications for activation of the front-line tuberculosis drug pyrazinamide. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 48. pp. 9176-9179.
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    abstract = "TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.",
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    Fyfe, PK, Rao, VA, Zemla, A, Cameron, S & Hunter, WN 2009, 'Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide', Angewandte Chemie - International Edition, vol. 48, no. 48, pp. 9176-9179. https://doi.org/10.1002/anie.200903407

    Specificity and mechanism of Acinetobacter baumanii nicotinamidase : implications for activation of the front-line tuberculosis drug pyrazinamide. / Fyfe, Paul K.; Rao, Vincenzo A.; Zemla, Aleksandra; Cameron, Scott; Hunter, William N.

    In: Angewandte Chemie - International Edition, Vol. 48, No. 48, 16.11.2009, p. 9176-9179.

    Research output: Contribution to journal › Article

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    AB - TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.

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    Fyfe PK, Rao VA, Zemla A, Cameron S, Hunter WN. Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide. Angewandte Chemie - International Edition. 2009 Nov 16;48(48):9176-9179. https://doi.org/10.1002/anie.200903407

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