Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Paul K. Fyfe; Vincenzo A. Rao; Aleksandra Zemla; Scott Cameron; William N. Hunter

doi:10.1002/anie.200903407

Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Paul K. Fyfe, Vincenzo A. Rao, Aleksandra Zemla, Scott Cameron, William N. Hunter

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.

Original language	English
Pages (from-to)	9176-9179
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	48
Early online date	26 Oct 2009
DOIs	https://doi.org/10.1002/anie.200903407
Publication status	Published - 16 Nov 2009
Externally published	Yes

Keywords

Drug discovery
Enzymes
Mechanisms
Tuberculosis
Zinc

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10.1002/anie.200903407

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abstract = "TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.",

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Specificity and mechanism of Acinetobacter baumanii nicotinamidase : implications for activation of the front-line tuberculosis drug pyrazinamide. / Fyfe, Paul K.; Rao, Vincenzo A.; Zemla, Aleksandra; Cameron, Scott; Hunter, William N.

In: Angewandte Chemie - International Edition, Vol. 48, No. 48, 16.11.2009, p. 9176-9179.

Research output: Contribution to journal › Article › peer-review

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T1 - Specificity and mechanism of Acinetobacter baumanii nicotinamidase

T2 - implications for activation of the front-line tuberculosis drug pyrazinamide

AU - Fyfe, Paul K.

AU - Rao, Vincenzo A.

AU - Zemla, Aleksandra

AU - Cameron, Scott

AU - Hunter, William N.

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AB - TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.

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DO - 10.1002/anie.200903407

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SN - 1433-7851

IS - 48

ER -

Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Abstract

Keywords

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