Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide

Paul K. Fyfe, Vincenzo A. Rao, Aleksandra Zemla, Scott Cameron, William N. Hunter

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.

    Original languageEnglish
    Pages (from-to)9176-9179
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume48
    Issue number48
    Early online date26 Oct 2009
    DOIs
    Publication statusPublished - 16 Nov 2009

    Fingerprint

    Nicotinamidase
    Pyrazinamide
    Niacin
    Crystal structure
    Chemical activation
    Acids
    Enzymes
    Pharmaceutical Preparations
    pyrazinoic acid

    Cite this

    @article{3e71dfefc4354bbd8429a27b137e3089,
    title = "Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide",
    abstract = "TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.",
    author = "Fyfe, {Paul K.} and Rao, {Vincenzo A.} and Aleksandra Zemla and Scott Cameron and Hunter, {William N.}",
    year = "2009",
    month = "11",
    day = "16",
    doi = "10.1002/anie.200903407",
    language = "English",
    volume = "48",
    pages = "9176--9179",
    journal = "Angewandte Chemie - International Edition",
    issn = "1433-7851",
    publisher = "John Wiley and Sons Ltd",
    number = "48",

    }

    Specificity and mechanism of Acinetobacter baumanii nicotinamidase : implications for activation of the front-line tuberculosis drug pyrazinamide. / Fyfe, Paul K.; Rao, Vincenzo A.; Zemla, Aleksandra; Cameron, Scott; Hunter, William N.

    In: Angewandte Chemie - International Edition, Vol. 48, No. 48, 16.11.2009, p. 9176-9179.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Specificity and mechanism of Acinetobacter baumanii nicotinamidase

    T2 - implications for activation of the front-line tuberculosis drug pyrazinamide

    AU - Fyfe, Paul K.

    AU - Rao, Vincenzo A.

    AU - Zemla, Aleksandra

    AU - Cameron, Scott

    AU - Hunter, William N.

    PY - 2009/11/16

    Y1 - 2009/11/16

    N2 - TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.

    AB - TB or not TB active: The high-resolution crystal structures (see picture) of the zinccontaining metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front-line anti-tuberculosis (TB) drug.

    U2 - 10.1002/anie.200903407

    DO - 10.1002/anie.200903407

    M3 - Article

    C2 - 19859929

    AN - SCOPUS:70449562067

    VL - 48

    SP - 9176

    EP - 9179

    JO - Angewandte Chemie - International Edition

    JF - Angewandte Chemie - International Edition

    SN - 1433-7851

    IS - 48

    ER -