Sperm cell mediated transgenesis: a review

Kevin R. Smith

doi:10.1080/10495399909525917

Sperm cell mediated transgenesis: a review

Kevin R. Smith

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Transgenesis would be greatly streamlined if sperm cells could be used as transgene vectors. Attempts to 'force' sperm cells to take up transgenes may be more worthy of further study than 'autouptake' attempts. However, thorough proof of its effectiveness will be required if sperm cell-mediated gene transfer is to be accepted, given the evolutionary implications associated with the possibility of sperm cells being able to transfer exogenous DNA.

Original language	English
Pages (from-to)	1-13
Number of pages	13
Journal	Animal Biotechnology
Volume	10
Issue number	1-2
DOIs	https://doi.org/10.1080/10495399909525917
Publication status	Published - 1999

Keywords

Genetic transformation

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10.1080/10495399909525917

The prospects for human germline genetic modification: scientific and bioethical considerations
Smith, K. (Author), Dec 2004
Student thesis: Doctoral Thesis

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abstract = "Transgenesis would be greatly streamlined if sperm cells could be used as transgene vectors. Attempts to 'force' sperm cells to take up transgenes may be more worthy of further study than 'autouptake' attempts. However, thorough proof of its effectiveness will be required if sperm cell-mediated gene transfer is to be accepted, given the evolutionary implications associated with the possibility of sperm cells being able to transfer exogenous DNA.",

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AB - Transgenesis would be greatly streamlined if sperm cells could be used as transgene vectors. Attempts to 'force' sperm cells to take up transgenes may be more worthy of further study than 'autouptake' attempts. However, thorough proof of its effectiveness will be required if sperm cell-mediated gene transfer is to be accepted, given the evolutionary implications associated with the possibility of sperm cells being able to transfer exogenous DNA.

U2 - 10.1080/10495399909525917

DO - 10.1080/10495399909525917

M3 - Review article

SN - 1049-5398

VL - 10

SP - 1

EP - 13

JO - Animal Biotechnology

JF - Animal Biotechnology

IS - 1-2

ER -

Sperm cell mediated transgenesis: a review

Abstract

Keywords

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Student theses

The prospects for human germline genetic modification: scientific and bioethical considerations

Cite this