Synthesis, DNA/protein binding and in vitro cytotoxic studies of new palladium metallothiosemicarbazones

R. Prabhakaran*, P. Kalaivani, P. Poornima, F. Dallemer, R. Huang, V. Vijaya Padma, K. Natarajan

*Corresponding author for this work

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Abstract

A series of four new thiosemicarbazone complexes of palladium have been synthesized, characterized and evaluated for their DNA/protein binding with CT-DNA and BSA, respectively. The new complexes bound to CT-DNA by intercalation mode and in protein binding studies, the complexes bound to BSA binding mechanism was found as static quenching. Among them the complex 4 had a strong binding affinity with BSA. In addition, in vitro cytotoxic studies were carried out on lung cancer (A549) and liver cancer (HepG2) cell lines and found that the complexes exhibited better activity than their parent thiosemicarbazone analogues. The complex 3 exhibited better activity than other complexes and this fact supported by the increased accumulation of the complexes in to the cancer cells which are evident from inter cellular uptake studies. (C) 2013 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)6742-6752
Number of pages11
JournalBioorganic and Medicinal Chemistry
Volume21
Issue number21
Early online date13 Aug 2013
DOIs
Publication statusPublished - 1 Nov 2013
Externally publishedYes

Cite this

Prabhakaran, R., Kalaivani, P., Poornima, P., Dallemer, F., Huang, R., Padma, V. V., & Natarajan, K. (2013). Synthesis, DNA/protein binding and in vitro cytotoxic studies of new palladium metallothiosemicarbazones. Bioorganic and Medicinal Chemistry, 21(21), 6742-6752. https://doi.org/10.1016/j.bmc.2013.08.005