Abstract
A series of four new thiosemicarbazone complexes of palladium have been synthesized, characterized and evaluated for their DNA/protein binding with CT-DNA and BSA, respectively. The new complexes bound to CT-DNA by intercalation mode and in protein binding studies, the complexes bound to BSA binding mechanism was found as static quenching. Among them the complex 4 had a strong binding affinity with BSA. In addition, in vitro cytotoxic studies were carried out on lung cancer (A549) and liver cancer (HepG2) cell lines and found that the complexes exhibited better activity than their parent thiosemicarbazone analogues. The complex 3 exhibited better activity than other complexes and this fact supported by the increased accumulation of the complexes in to the cancer cells which are evident from inter cellular uptake studies. (C) 2013 Elsevier Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 6742-6752 |
| Number of pages | 11 |
| Journal | Bioorganic and Medicinal Chemistry |
| Volume | 21 |
| Issue number | 21 |
| Early online date | 13 Aug 2013 |
| DOIs | |
| Publication status | Published - 1 Nov 2013 |
| Externally published | Yes |
Cite this
}
Synthesis, DNA/protein binding and in vitro cytotoxic studies of new palladium metallothiosemicarbazones. / Prabhakaran, R.; Kalaivani, P.; Poornima, P.; Dallemer, F.; Huang, R.; Padma, V. Vijaya; Natarajan, K.
In: Bioorganic and Medicinal Chemistry, Vol. 21, No. 21, 01.11.2013, p. 6742-6752.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis, DNA/protein binding and in vitro cytotoxic studies of new palladium metallothiosemicarbazones
AU - Prabhakaran, R.
AU - Kalaivani, P.
AU - Poornima, P.
AU - Dallemer, F.
AU - Huang, R.
AU - Padma, V. Vijaya
AU - Natarajan, K.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - A series of four new thiosemicarbazone complexes of palladium have been synthesized, characterized and evaluated for their DNA/protein binding with CT-DNA and BSA, respectively. The new complexes bound to CT-DNA by intercalation mode and in protein binding studies, the complexes bound to BSA binding mechanism was found as static quenching. Among them the complex 4 had a strong binding affinity with BSA. In addition, in vitro cytotoxic studies were carried out on lung cancer (A549) and liver cancer (HepG2) cell lines and found that the complexes exhibited better activity than their parent thiosemicarbazone analogues. The complex 3 exhibited better activity than other complexes and this fact supported by the increased accumulation of the complexes in to the cancer cells which are evident from inter cellular uptake studies. (C) 2013 Elsevier Ltd. All rights reserved.
AB - A series of four new thiosemicarbazone complexes of palladium have been synthesized, characterized and evaluated for their DNA/protein binding with CT-DNA and BSA, respectively. The new complexes bound to CT-DNA by intercalation mode and in protein binding studies, the complexes bound to BSA binding mechanism was found as static quenching. Among them the complex 4 had a strong binding affinity with BSA. In addition, in vitro cytotoxic studies were carried out on lung cancer (A549) and liver cancer (HepG2) cell lines and found that the complexes exhibited better activity than their parent thiosemicarbazone analogues. The complex 3 exhibited better activity than other complexes and this fact supported by the increased accumulation of the complexes in to the cancer cells which are evident from inter cellular uptake studies. (C) 2013 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.bmc.2013.08.005
DO - 10.1016/j.bmc.2013.08.005
M3 - Article
VL - 21
SP - 6742
EP - 6752
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 21
ER -