Abstract
The reaction of salicylaldehyde-4(N)-ethylthiosemicarbazone, [H-2-(Sal-etsc)] with [RuHCl(CO)(PPh3)(3)] afforded two isomeric ruthenium(II) carbonyl complexes namely [Ru(H-Sal-etsc)(CO)Cl(PPh3)(2)] (1) and [Ru(Sal-etsc)(CO)(PPh3)(2)]center dot Cl (2). The new complexes were characterized by various spectroscopic techniques (IR, Electronic, H-1 NMR and P-31 NMR) and X-ray crystallography. In this reaction, bidentate monobasic coordination with the formation of more strain NS four member chelate in (1) and tridentate monobasic coordination with the formation of ONS five and six member rings in (2) were observed. The binding interaction of complexes (1 and 2) to calf thymus(CT) DNA/Lysozyme has been explored. The cytotoxic nature of the complexes was evaluated on human lung/liver cancer cells, A549 and HepG2. (C) 2014 Elsevier B. V. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 67-80 |
| Number of pages | 14 |
| Journal | Journal of Organometallic Chemistry |
| Volume | 762 |
| Early online date | 13 Apr 2014 |
| DOIs | |
| Publication status | Published - 15 Jul 2014 |
| Externally published | Yes |
Cite this
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Synthesis, structural characterization, DNA/Protein binding and in vitro cytotoxicity of isomeric ruthenium carbonyl complexes. / Kalaivani, P.; Prabhakaran, R.; Dallemer, F.; Vaishnavi, E.; Poornima, P.; Padma, V. Vijaya; Renganathan, R.; Natarajan, K.
In: Journal of Organometallic Chemistry, Vol. 762, 15.07.2014, p. 67-80.Research output: Contribution to journal › Article
TY - JOUR
T1 - Synthesis, structural characterization, DNA/Protein binding and in vitro cytotoxicity of isomeric ruthenium carbonyl complexes
AU - Kalaivani, P.
AU - Prabhakaran, R.
AU - Dallemer, F.
AU - Vaishnavi, E.
AU - Poornima, P.
AU - Padma, V. Vijaya
AU - Renganathan, R.
AU - Natarajan, K.
PY - 2014/7/15
Y1 - 2014/7/15
N2 - The reaction of salicylaldehyde-4(N)-ethylthiosemicarbazone, [H-2-(Sal-etsc)] with [RuHCl(CO)(PPh3)(3)] afforded two isomeric ruthenium(II) carbonyl complexes namely [Ru(H-Sal-etsc)(CO)Cl(PPh3)(2)] (1) and [Ru(Sal-etsc)(CO)(PPh3)(2)]center dot Cl (2). The new complexes were characterized by various spectroscopic techniques (IR, Electronic, H-1 NMR and P-31 NMR) and X-ray crystallography. In this reaction, bidentate monobasic coordination with the formation of more strain NS four member chelate in (1) and tridentate monobasic coordination with the formation of ONS five and six member rings in (2) were observed. The binding interaction of complexes (1 and 2) to calf thymus(CT) DNA/Lysozyme has been explored. The cytotoxic nature of the complexes was evaluated on human lung/liver cancer cells, A549 and HepG2. (C) 2014 Elsevier B. V. All rights reserved.
AB - The reaction of salicylaldehyde-4(N)-ethylthiosemicarbazone, [H-2-(Sal-etsc)] with [RuHCl(CO)(PPh3)(3)] afforded two isomeric ruthenium(II) carbonyl complexes namely [Ru(H-Sal-etsc)(CO)Cl(PPh3)(2)] (1) and [Ru(Sal-etsc)(CO)(PPh3)(2)]center dot Cl (2). The new complexes were characterized by various spectroscopic techniques (IR, Electronic, H-1 NMR and P-31 NMR) and X-ray crystallography. In this reaction, bidentate monobasic coordination with the formation of more strain NS four member chelate in (1) and tridentate monobasic coordination with the formation of ONS five and six member rings in (2) were observed. The binding interaction of complexes (1 and 2) to calf thymus(CT) DNA/Lysozyme has been explored. The cytotoxic nature of the complexes was evaluated on human lung/liver cancer cells, A549 and HepG2. (C) 2014 Elsevier B. V. All rights reserved.
U2 - 10.1016/j.jorganchem.2014.04.003
DO - 10.1016/j.jorganchem.2014.04.003
M3 - Article
VL - 762
SP - 67
EP - 80
JO - Journal of Organometallic Chemistry
JF - Journal of Organometallic Chemistry
SN - 0022-328X
ER -