Tendon collagen synthesis at rest and after exercise in women

Benjamin F. Miller, Mette Hansen, Jens L. Olsen, Peter Schwarz, John A. Babraj, Kenneth Smith, Michael J. Rennie, Michael Kjaer

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

In general, there is a higher incidence of musculoskeletal injuries during physical activity in women than in men. We hypothesized that in women rates of tendon collagen synthesis would be lower than in men at rest and after exercise, especially in the later luteal phase when estrogen and progesterone concentrations are higher than the early follicular phase. We studied tendon collagen fractional synthesis rate (FSR) in 15 young, healthy female subjects in either the early follicular (n = 8) or the late luteal phase (n = 7) 72 h after an acute bout of one-legged exercise (60 min kicking at 67% workload maximum) (72 h) and compared the results with those previously obtained for men. Samples were taken from the patellar tendon in both the exercised and rested legs to determine collagen FSR by the incorporation of [15N]proline into tendon collagen hydroxyproline. There was no effect of menstrual phase on tendon collagen synthesis either at rest or after exercise. However, there was a significant difference between women and men at rest (women = 0.025 ± 0.002%/h, men = 0.045 ± 0.008%/h; P < 0.05) and 72 h after exercise (women = 0.027 ± 0.005%/h; men = 0.058 ± 0.008%/h). Furthermore, rest and 72-h tendon collagen synthesis were not different in women, whereas in men tendon collagen synthesis remained significantly elevated 72 h after exercise. It is concluded that both in the resting state and after exercise, tendon collagen FSR is lower in women than in men, which may contribute to a lower rate of tissue repair after exercise.
Original languageEnglish
Pages (from-to)541-546
Number of pages6
JournalJournal of Applied Physiology
Volume102
Issue number2
DOIs
Publication statusPublished - 1 Feb 2007
Externally publishedYes

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Tendons
Collagen
Exercise
Luteal Phase
Patellar Ligament
Follicular Phase
Hydroxyproline
Workload
Proline
Progesterone
Leg
Healthy Volunteers
Estrogens
Incidence
Wounds and Injuries

Cite this

Miller, B. F., Hansen, M., Olsen, J. L., Schwarz, P., Babraj, J. A., Smith, K., ... Kjaer, M. (2007). Tendon collagen synthesis at rest and after exercise in women. Journal of Applied Physiology, 102(2), 541-546. https://doi.org/10.1152/japplphysiol.00797.2006
Miller, Benjamin F. ; Hansen, Mette ; Olsen, Jens L. ; Schwarz, Peter ; Babraj, John A. ; Smith, Kenneth ; Rennie, Michael J. ; Kjaer, Michael. / Tendon collagen synthesis at rest and after exercise in women. In: Journal of Applied Physiology. 2007 ; Vol. 102, No. 2. pp. 541-546.
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Miller, BF, Hansen, M, Olsen, JL, Schwarz, P, Babraj, JA, Smith, K, Rennie, MJ & Kjaer, M 2007, 'Tendon collagen synthesis at rest and after exercise in women', Journal of Applied Physiology, vol. 102, no. 2, pp. 541-546. https://doi.org/10.1152/japplphysiol.00797.2006

Tendon collagen synthesis at rest and after exercise in women. / Miller, Benjamin F.; Hansen, Mette; Olsen, Jens L.; Schwarz, Peter; Babraj, John A.; Smith, Kenneth; Rennie, Michael J.; Kjaer, Michael.

In: Journal of Applied Physiology, Vol. 102, No. 2, 01.02.2007, p. 541-546.

Research output: Contribution to journalArticle

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T1 - Tendon collagen synthesis at rest and after exercise in women

AU - Miller, Benjamin F.

AU - Hansen, Mette

AU - Olsen, Jens L.

AU - Schwarz, Peter

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AU - Smith, Kenneth

AU - Rennie, Michael J.

AU - Kjaer, Michael

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Y1 - 2007/2/1

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AB - In general, there is a higher incidence of musculoskeletal injuries during physical activity in women than in men. We hypothesized that in women rates of tendon collagen synthesis would be lower than in men at rest and after exercise, especially in the later luteal phase when estrogen and progesterone concentrations are higher than the early follicular phase. We studied tendon collagen fractional synthesis rate (FSR) in 15 young, healthy female subjects in either the early follicular (n = 8) or the late luteal phase (n = 7) 72 h after an acute bout of one-legged exercise (60 min kicking at 67% workload maximum) (72 h) and compared the results with those previously obtained for men. Samples were taken from the patellar tendon in both the exercised and rested legs to determine collagen FSR by the incorporation of [15N]proline into tendon collagen hydroxyproline. There was no effect of menstrual phase on tendon collagen synthesis either at rest or after exercise. However, there was a significant difference between women and men at rest (women = 0.025 ± 0.002%/h, men = 0.045 ± 0.008%/h; P < 0.05) and 72 h after exercise (women = 0.027 ± 0.005%/h; men = 0.058 ± 0.008%/h). Furthermore, rest and 72-h tendon collagen synthesis were not different in women, whereas in men tendon collagen synthesis remained significantly elevated 72 h after exercise. It is concluded that both in the resting state and after exercise, tendon collagen FSR is lower in women than in men, which may contribute to a lower rate of tissue repair after exercise.

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