The antimicrobial activity of oil-in-water microemulsions is predicted by their position within the microemulsion stability zone

I. S. I. Al-Adham, Ali Al-Nawajeh, Enam Khalil, Phillip J. Collier

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Abstract

It has been shown previously that thermodynamically stable oil-in-water microemulsions have significant antimicrobial activity against planktonic cells and biofilm cells over short periods of exposure. It was the aim of this study to identify whether the position of the microemulsion within the microemulsion stability zone of the pseudo-ternary phase structure predicts the efficiency of the antimicrobial action of the microemulsion. Microemulsions were formulated at different points within the microemulsion stability zone. Experiments were performed to observe the kinetics of killing of these microemulsions against selected test microorganisms (Pseudomonas aeruginosa ATCC 9027, Candida albicans ATCC 10231, Staphylococcus aureus ATCC 6538 and Aspergillus niger ATCC 16404). The results indicated that the antimicrobial activity of the microemulsion is dependant upon its position within the zone of stability and is greater nearer the centre of that zone. The results indicate that significant antimicrobial activity can be observed at all points within the zone of microemulsion stability, but that maximal activity is to be found at the centre of that area.
Original languageEnglish
Number of pages8
JournalThe International Arabic Journal of Antimicrobial Agents
Volume2
Issue number2.2
DOIs
Publication statusPublished - 2012

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antimicrobial activity
oil
water
biofilm
microorganism
kinetics
experiment

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title = "The antimicrobial activity of oil-in-water microemulsions is predicted by their position within the microemulsion stability zone",
abstract = "It has been shown previously that thermodynamically stable oil-in-water microemulsions have significant antimicrobial activity against planktonic cells and biofilm cells over short periods of exposure. It was the aim of this study to identify whether the position of the microemulsion within the microemulsion stability zone of the pseudo-ternary phase structure predicts the efficiency of the antimicrobial action of the microemulsion. Microemulsions were formulated at different points within the microemulsion stability zone. Experiments were performed to observe the kinetics of killing of these microemulsions against selected test microorganisms (Pseudomonas aeruginosa ATCC 9027, Candida albicans ATCC 10231, Staphylococcus aureus ATCC 6538 and Aspergillus niger ATCC 16404). The results indicated that the antimicrobial activity of the microemulsion is dependant upon its position within the zone of stability and is greater nearer the centre of that zone. The results indicate that significant antimicrobial activity can be observed at all points within the zone of microemulsion stability, but that maximal activity is to be found at the centre of that area.",
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The antimicrobial activity of oil-in-water microemulsions is predicted by their position within the microemulsion stability zone. / Al-Adham, I. S. I.; Al-Nawajeh, Ali; Khalil, Enam; Collier, Phillip J.

In: The International Arabic Journal of Antimicrobial Agents, Vol. 2, No. 2.2, 2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The antimicrobial activity of oil-in-water microemulsions is predicted by their position within the microemulsion stability zone

AU - Al-Adham, I. S. I.

AU - Al-Nawajeh, Ali

AU - Khalil, Enam

AU - Collier, Phillip J.

PY - 2012

Y1 - 2012

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AB - It has been shown previously that thermodynamically stable oil-in-water microemulsions have significant antimicrobial activity against planktonic cells and biofilm cells over short periods of exposure. It was the aim of this study to identify whether the position of the microemulsion within the microemulsion stability zone of the pseudo-ternary phase structure predicts the efficiency of the antimicrobial action of the microemulsion. Microemulsions were formulated at different points within the microemulsion stability zone. Experiments were performed to observe the kinetics of killing of these microemulsions against selected test microorganisms (Pseudomonas aeruginosa ATCC 9027, Candida albicans ATCC 10231, Staphylococcus aureus ATCC 6538 and Aspergillus niger ATCC 16404). The results indicated that the antimicrobial activity of the microemulsion is dependant upon its position within the zone of stability and is greater nearer the centre of that zone. The results indicate that significant antimicrobial activity can be observed at all points within the zone of microemulsion stability, but that maximal activity is to be found at the centre of that area.

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