The effects of low-volume high-intensity interval training on pulmonary oxygen uptake and muscle deoxygentaion kinetics during heavy intensity exercise in type 2 diabetes.

Aaron Nevin, Adam McDermott, Norita Gildea, Joel Rocha, Domenico Crognale, Simon Green, Donal O'Shea, Mikel Egana

Research output: Contribution to conferenceAbstract

Abstract

We tested the hypothesis that a 12 week intervention involving low-volume high-intensity interval training (LVHIIT) would increase the speed of the adjustment of the primary phase (taup, τp) of pulmonary oxygen uptake (VO2) and/or reduce the amplitude of the slow component of VO2 during high-intensity cycling in type 2 diabetes (T2D) to a similar extend as a traditional moderate-intensity continuous training (MICT) intervention. Twenty eight middle-aged participants with T2D (17 men, mean ± SD: age 53 ± 10 yr, body mass index 30.0 ± 4.0 kg.m-2) were randomly assigned to MICT (n=10, 50 min of moderate-intensity cycling) or LVHIIT (n=9, 10 x 1 min at ~90% maximal heart rate interspersed by 1 min of ‘unloaded' cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week and every 3 weeks exercise intensity was adjusted. Before and after the intervention participants completed two bouts of constant-load cycling corresponding to 50% between their ventilatory threshold and peak VO2 power outputs (i.e. 50%Δ) previously established during a ramp incremental test. VO2 kinetics were calculated from continuously measured breath-by-breath VO2 data, whilst the rates of muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) were continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. VO2 and Δ[HHb+Mb] responses were modelled using a bi-exponential model. Time point analysis of VO2 and [HHb+Mb] responses were performed using a two-way ANOVA. Values are mean ± SD. The VO2τp were speeded by a similar magnitude in both MICT (Pre: 33.6 ± 5.1, Post: 24.7 ± 5.1 s; P < 0.05) and LVHIIT (Pre: 30.7 ± 5.3, Post: 26.4 ± 2.7 s; P < 0.05) but no effect was observed for the same parameter for the control group. Similarly, the overall mean response time of the VO2 response (fitted by a mono-exponential model) in both training groups was significantly speeded, but not in the control group. The amplitude of the VO2 slow component (As) was reduced in the MICT group only. There were no changes between or within group pre and post intervention for muscle deoxygenation parameters. In middle-aged individuals with T2D, MICT and LVHIIT enhanced VO2 kinetics responses during high intensity exercise likely consequent to a training-induced increase in muscle blood flow and/or improved muscle perfusion to metabolic rate.
Original languageEnglish
Publication statusPublished - 14 Sep 2018
EventEurophysiology 2018 - QEII Centre, London, United Kingdom
Duration: 14 Sep 201816 Sep 2018
https://www.europhysiology2018.org/

Conference

ConferenceEurophysiology 2018
CountryUnited Kingdom
CityLondon
Period14/09/1816/09/18
Internet address

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Type 2 Diabetes Mellitus
Exercise
Oxygen
Muscles
Lung
Control Groups
Architectural Accessibility
Near-Infrared Spectroscopy
Myoglobin
Quadriceps Muscle
Reaction Time
Analysis of Variance
Hemoglobins
Body Mass Index
Perfusion
Heart Rate
High-Intensity Interval Training

Cite this

Nevin, A., McDermott, A., Gildea, N., Rocha, J., Crognale, D., Green, S., ... Egana, M. (2018). The effects of low-volume high-intensity interval training on pulmonary oxygen uptake and muscle deoxygentaion kinetics during heavy intensity exercise in type 2 diabetes.. Abstract from Europhysiology 2018, London, United Kingdom.
Nevin, Aaron ; McDermott, Adam ; Gildea, Norita ; Rocha, Joel ; Crognale, Domenico ; Green, Simon ; O'Shea, Donal ; Egana, Mikel. / The effects of low-volume high-intensity interval training on pulmonary oxygen uptake and muscle deoxygentaion kinetics during heavy intensity exercise in type 2 diabetes. Abstract from Europhysiology 2018, London, United Kingdom.
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abstract = "We tested the hypothesis that a 12 week intervention involving low-volume high-intensity interval training (LVHIIT) would increase the speed of the adjustment of the primary phase (taup, τp) of pulmonary oxygen uptake (VO2) and/or reduce the amplitude of the slow component of VO2 during high-intensity cycling in type 2 diabetes (T2D) to a similar extend as a traditional moderate-intensity continuous training (MICT) intervention. Twenty eight middle-aged participants with T2D (17 men, mean ± SD: age 53 ± 10 yr, body mass index 30.0 ± 4.0 kg.m-2) were randomly assigned to MICT (n=10, 50 min of moderate-intensity cycling) or LVHIIT (n=9, 10 x 1 min at ~90{\%} maximal heart rate interspersed by 1 min of ‘unloaded' cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week and every 3 weeks exercise intensity was adjusted. Before and after the intervention participants completed two bouts of constant-load cycling corresponding to 50{\%} between their ventilatory threshold and peak VO2 power outputs (i.e. 50{\%}Δ) previously established during a ramp incremental test. VO2 kinetics were calculated from continuously measured breath-by-breath VO2 data, whilst the rates of muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) were continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. VO2 and Δ[HHb+Mb] responses were modelled using a bi-exponential model. Time point analysis of VO2 and [HHb+Mb] responses were performed using a two-way ANOVA. Values are mean ± SD. The VO2τp were speeded by a similar magnitude in both MICT (Pre: 33.6 ± 5.1, Post: 24.7 ± 5.1 s; P < 0.05) and LVHIIT (Pre: 30.7 ± 5.3, Post: 26.4 ± 2.7 s; P < 0.05) but no effect was observed for the same parameter for the control group. Similarly, the overall mean response time of the VO2 response (fitted by a mono-exponential model) in both training groups was significantly speeded, but not in the control group. The amplitude of the VO2 slow component (As) was reduced in the MICT group only. There were no changes between or within group pre and post intervention for muscle deoxygenation parameters. In middle-aged individuals with T2D, MICT and LVHIIT enhanced VO2 kinetics responses during high intensity exercise likely consequent to a training-induced increase in muscle blood flow and/or improved muscle perfusion to metabolic rate.",
author = "Aaron Nevin and Adam McDermott and Norita Gildea and Joel Rocha and Domenico Crognale and Simon Green and Donal O'Shea and Mikel Egana",
year = "2018",
month = "9",
day = "14",
language = "English",
note = "Europhysiology 2018 ; Conference date: 14-09-2018 Through 16-09-2018",
url = "https://www.europhysiology2018.org/",

}

Nevin, A, McDermott, A, Gildea, N, Rocha, J, Crognale, D, Green, S, O'Shea, D & Egana, M 2018, 'The effects of low-volume high-intensity interval training on pulmonary oxygen uptake and muscle deoxygentaion kinetics during heavy intensity exercise in type 2 diabetes.' Europhysiology 2018, London, United Kingdom, 14/09/18 - 16/09/18, .

The effects of low-volume high-intensity interval training on pulmonary oxygen uptake and muscle deoxygentaion kinetics during heavy intensity exercise in type 2 diabetes. / Nevin, Aaron; McDermott, Adam; Gildea, Norita; Rocha, Joel; Crognale, Domenico; Green, Simon; O'Shea, Donal; Egana, Mikel.

2018. Abstract from Europhysiology 2018, London, United Kingdom.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - The effects of low-volume high-intensity interval training on pulmonary oxygen uptake and muscle deoxygentaion kinetics during heavy intensity exercise in type 2 diabetes.

AU - Nevin, Aaron

AU - McDermott, Adam

AU - Gildea, Norita

AU - Rocha, Joel

AU - Crognale, Domenico

AU - Green, Simon

AU - O'Shea, Donal

AU - Egana, Mikel

PY - 2018/9/14

Y1 - 2018/9/14

N2 - We tested the hypothesis that a 12 week intervention involving low-volume high-intensity interval training (LVHIIT) would increase the speed of the adjustment of the primary phase (taup, τp) of pulmonary oxygen uptake (VO2) and/or reduce the amplitude of the slow component of VO2 during high-intensity cycling in type 2 diabetes (T2D) to a similar extend as a traditional moderate-intensity continuous training (MICT) intervention. Twenty eight middle-aged participants with T2D (17 men, mean ± SD: age 53 ± 10 yr, body mass index 30.0 ± 4.0 kg.m-2) were randomly assigned to MICT (n=10, 50 min of moderate-intensity cycling) or LVHIIT (n=9, 10 x 1 min at ~90% maximal heart rate interspersed by 1 min of ‘unloaded' cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week and every 3 weeks exercise intensity was adjusted. Before and after the intervention participants completed two bouts of constant-load cycling corresponding to 50% between their ventilatory threshold and peak VO2 power outputs (i.e. 50%Δ) previously established during a ramp incremental test. VO2 kinetics were calculated from continuously measured breath-by-breath VO2 data, whilst the rates of muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) were continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. VO2 and Δ[HHb+Mb] responses were modelled using a bi-exponential model. Time point analysis of VO2 and [HHb+Mb] responses were performed using a two-way ANOVA. Values are mean ± SD. The VO2τp were speeded by a similar magnitude in both MICT (Pre: 33.6 ± 5.1, Post: 24.7 ± 5.1 s; P < 0.05) and LVHIIT (Pre: 30.7 ± 5.3, Post: 26.4 ± 2.7 s; P < 0.05) but no effect was observed for the same parameter for the control group. Similarly, the overall mean response time of the VO2 response (fitted by a mono-exponential model) in both training groups was significantly speeded, but not in the control group. The amplitude of the VO2 slow component (As) was reduced in the MICT group only. There were no changes between or within group pre and post intervention for muscle deoxygenation parameters. In middle-aged individuals with T2D, MICT and LVHIIT enhanced VO2 kinetics responses during high intensity exercise likely consequent to a training-induced increase in muscle blood flow and/or improved muscle perfusion to metabolic rate.

AB - We tested the hypothesis that a 12 week intervention involving low-volume high-intensity interval training (LVHIIT) would increase the speed of the adjustment of the primary phase (taup, τp) of pulmonary oxygen uptake (VO2) and/or reduce the amplitude of the slow component of VO2 during high-intensity cycling in type 2 diabetes (T2D) to a similar extend as a traditional moderate-intensity continuous training (MICT) intervention. Twenty eight middle-aged participants with T2D (17 men, mean ± SD: age 53 ± 10 yr, body mass index 30.0 ± 4.0 kg.m-2) were randomly assigned to MICT (n=10, 50 min of moderate-intensity cycling) or LVHIIT (n=9, 10 x 1 min at ~90% maximal heart rate interspersed by 1 min of ‘unloaded' cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week and every 3 weeks exercise intensity was adjusted. Before and after the intervention participants completed two bouts of constant-load cycling corresponding to 50% between their ventilatory threshold and peak VO2 power outputs (i.e. 50%Δ) previously established during a ramp incremental test. VO2 kinetics were calculated from continuously measured breath-by-breath VO2 data, whilst the rates of muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) were continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. VO2 and Δ[HHb+Mb] responses were modelled using a bi-exponential model. Time point analysis of VO2 and [HHb+Mb] responses were performed using a two-way ANOVA. Values are mean ± SD. The VO2τp were speeded by a similar magnitude in both MICT (Pre: 33.6 ± 5.1, Post: 24.7 ± 5.1 s; P < 0.05) and LVHIIT (Pre: 30.7 ± 5.3, Post: 26.4 ± 2.7 s; P < 0.05) but no effect was observed for the same parameter for the control group. Similarly, the overall mean response time of the VO2 response (fitted by a mono-exponential model) in both training groups was significantly speeded, but not in the control group. The amplitude of the VO2 slow component (As) was reduced in the MICT group only. There were no changes between or within group pre and post intervention for muscle deoxygenation parameters. In middle-aged individuals with T2D, MICT and LVHIIT enhanced VO2 kinetics responses during high intensity exercise likely consequent to a training-induced increase in muscle blood flow and/or improved muscle perfusion to metabolic rate.

M3 - Abstract

ER -

Nevin A, McDermott A, Gildea N, Rocha J, Crognale D, Green S et al. The effects of low-volume high-intensity interval training on pulmonary oxygen uptake and muscle deoxygentaion kinetics during heavy intensity exercise in type 2 diabetes.. 2018. Abstract from Europhysiology 2018, London, United Kingdom.