The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group

Keith R. Sturrock, David H. Bremner, Grant Wishart

Research output: Contribution to journal › Special issue

  • 2 Citations

Abstract

The base catalysed reaction of carbon disulphide with the active methylene groups of chloropyridines 4 and 7, followed by alkylation with reagents which also contain active methylene groups, lead to ketene dithioacetals. Further reaction with base afforded highly substituted thiophenes.
Original languageEnglish
Pages (from-to)1657 - 1662
Number of pages6
JournalHeterocycles
Volume82
Issue number2
DOIs
StatePublished - Mar 2011

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Carbon Disulfide
Thiophenes
Alkylation
Aortic Aneurysm

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Sturrock, Keith R.; Bremner, David H.; Wishart, Grant / The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group.

In: Heterocycles, Vol. 82, No. 2, 03.2011, p. 1657 - 1662.

Research output: Contribution to journal › Special issue

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abstract = "The base catalysed reaction of carbon disulphide with the active methylene groups of chloropyridines 4 and 7, followed by alkylation with reagents which also contain active methylene groups, lead to ketene dithioacetals. Further reaction with base afforded highly substituted thiophenes.",
author = "Sturrock, {Keith R.} and Bremner, {David H.} and Grant Wishart",
year = "2011",
month = "3",
doi = "10.3987/COM-10-S(E)59",
volume = "82",
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journal = "Heterocycles",
issn = "0385-5414",
publisher = "Japan Institute of Heterocyclic Chemistry",
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Sturrock, KR, Bremner, DH & Wishart, G 2011, 'The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group' Heterocycles, vol 82, no. 2, pp. 1657 - 1662. DOI: 10.3987/COM-10-S(E)59

The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group. / Sturrock, Keith R.; Bremner, David H.; Wishart, Grant.

In: Heterocycles, Vol. 82, No. 2, 03.2011, p. 1657 - 1662.

Research output: Contribution to journal › Special issue

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T1 - The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group

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AU - Bremner,David H.

AU - Wishart,Grant

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AB - The base catalysed reaction of carbon disulphide with the active methylene groups of chloropyridines 4 and 7, followed by alkylation with reagents which also contain active methylene groups, lead to ketene dithioacetals. Further reaction with base afforded highly substituted thiophenes.

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DO - 10.3987/COM-10-S(E)59

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JO - Heterocycles

T2 - Heterocycles

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Sturrock KR, Bremner DH, Wishart G. The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group. Heterocycles. 2011 Mar;82(2):1657 - 1662. Available from, DOI: 10.3987/COM-10-S(E)59

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