The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group

Keith R. Sturrock, David H. Bremner, Grant Wishart

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    3 Citations (Scopus)
    307 Downloads (Pure)

    Abstract

    The base catalysed reaction of carbon disulphide with the active methylene groups of chloropyridines 4 and 7, followed by alkylation with reagents which also contain active methylene groups, lead to ketene dithioacetals. Further reaction with base afforded highly substituted thiophenes.
    Original languageEnglish
    Pages (from-to)1657 - 1662
    Number of pages6
    JournalHeterocycles
    Volume82
    Issue number2
    DOIs
    Publication statusPublished - Mar 2011

    Keywords

    • Base catalysed
    • Thorpe reaction
    • Dieckmann reaction
    • Carbon disulfide
    • Cyclization

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