The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group

Keith R. Sturrock, David H. Bremner, Grant Wishart

Research output: Contribution to journalSpecial issue

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Abstract

The base catalysed reaction of carbon disulphide with the active methylene groups of chloropyridines 4 and 7, followed by alkylation with reagents which also contain active methylene groups, lead to ketene dithioacetals. Further reaction with base afforded highly substituted thiophenes.
Original languageEnglish
Pages (from-to)1657 - 1662
Number of pages6
JournalHeterocycles
Volume82
Issue number2
DOIs
StatePublished - Mar 2011

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Carbon Disulfide
Thiophenes
Alkylation
Aortic Aneurysm

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Sturrock, Keith R.; Bremner, David H.; Wishart, Grant / The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group.

In: Heterocycles, Vol. 82, No. 2, 03.2011, p. 1657 - 1662.

Research output: Contribution to journalSpecial issue

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abstract = "The base catalysed reaction of carbon disulphide with the active methylene groups of chloropyridines 4 and 7, followed by alkylation with reagents which also contain active methylene groups, lead to ketene dithioacetals. Further reaction with base afforded highly substituted thiophenes.",
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The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group. / Sturrock, Keith R.; Bremner, David H.; Wishart, Grant.

In: Heterocycles, Vol. 82, No. 2, 03.2011, p. 1657 - 1662.

Research output: Contribution to journalSpecial issue

TY - JOUR

T1 - The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group

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AU - Bremner,David H.

AU - Wishart,Grant

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AB - The base catalysed reaction of carbon disulphide with the active methylene groups of chloropyridines 4 and 7, followed by alkylation with reagents which also contain active methylene groups, lead to ketene dithioacetals. Further reaction with base afforded highly substituted thiophenes.

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