Indecisiveness is an inability to make a decision, manifest across a number of behaviours. We explore the influence that both direction and strength of hand preference may have on this construct, examining it in relation to the revised Reinforcement Sensitivity Theory (rRST). Frost and Shows’ (1993) Indecisiveness Scale was administered to 328 undergraduates (221 females), alongside the Edinburgh Handedness Inventory (Oldfield, 1971) and Carver and White’s (1994) BIS/BAS scales. Simple correlations showed left-handers had a positive relationship between strength of handedness and BIS. In right-handers, strength and aversive indecision were positively correlated. Regression analysis demonstrated no significant relationship between hand strength and indecision, but that indecision was related to all three measures of rRST. Consistent with previous work, BIS was positively related to all indecision but particularly aversive, while BAS was negatively related to indecision but most strongly the avoidant category. We found that FFFS is more closely related to aversive than avoidant indecision. The relationship between rRST and indecision may be influenced by handedness; for right-handers the same pattern was found, but in left-handers BAS was not a significant predictor of indecision, BIS only predicted aversive indecision and FFFS predicted all three categories.