The synthesis of thienopyridines from ortho-halogenated pyridine derivatives; Part 2

D. H. Bremner*, A. D. Dunn, K. A. Wilson, K. R. Sturrock, G. Wishart

*Corresponding author for this work

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Synthetic routes to the ortho-halogenated pyridine derivatives, ethyl 2- and 4-chloro-3-pyridylacetate, ethyl 3-bromo-4-pyridylacetate and ethyl 3-bromo-2-pyridylacetate, which have methylene groups activated by the ester functionality are reported. Reaction of these pyridines with carbon disulfide in the presence of sodium hydride, followed by quenching with iodomethane, results in the formation of the corresponding thienopyridines in moderate yields.

    Original languageEnglish
    Pages (from-to)949-952
    Number of pages4
    JournalSynthesis
    Volume1997
    Issue number8
    DOIs
    Publication statusPublished - 1 Jan 1997

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