Abstract
Synthetic routes to the ortho-halogenated pyridine derivatives, ethyl 2- and 4-chloro-3-pyridylacetate, ethyl 3-bromo-4-pyridylacetate and ethyl 3-bromo-2-pyridylacetate, which have methylene groups activated by the ester functionality are reported. Reaction of these pyridines with carbon disulfide in the presence of sodium hydride, followed by quenching with iodomethane, results in the formation of the corresponding thienopyridines in moderate yields.
| Original language | English |
|---|---|
| Pages (from-to) | 949-952 |
| Number of pages | 4 |
| Journal | Synthesis |
| Volume | 1997 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1 Jan 1997 |
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The synthesis of thienopyridines from ortho-halogenated pyridine derivatives; Part 2. / Bremner, D. H.; Dunn, A. D.; Wilson, K. A.; Sturrock, K. R.; Wishart, G.
In: Synthesis, Vol. 1997, No. 8, 01.01.1997, p. 949-952.Research output: Contribution to journal › Article
TY - JOUR
T1 - The synthesis of thienopyridines from ortho-halogenated pyridine derivatives; Part 2
AU - Bremner, D. H.
AU - Dunn, A. D.
AU - Wilson, K. A.
AU - Sturrock, K. R.
AU - Wishart, G.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Synthetic routes to the ortho-halogenated pyridine derivatives, ethyl 2- and 4-chloro-3-pyridylacetate, ethyl 3-bromo-4-pyridylacetate and ethyl 3-bromo-2-pyridylacetate, which have methylene groups activated by the ester functionality are reported. Reaction of these pyridines with carbon disulfide in the presence of sodium hydride, followed by quenching with iodomethane, results in the formation of the corresponding thienopyridines in moderate yields.
AB - Synthetic routes to the ortho-halogenated pyridine derivatives, ethyl 2- and 4-chloro-3-pyridylacetate, ethyl 3-bromo-4-pyridylacetate and ethyl 3-bromo-2-pyridylacetate, which have methylene groups activated by the ester functionality are reported. Reaction of these pyridines with carbon disulfide in the presence of sodium hydride, followed by quenching with iodomethane, results in the formation of the corresponding thienopyridines in moderate yields.
U2 - 10.1055/s-1997-1289
DO - 10.1055/s-1997-1289
M3 - Article
AN - SCOPUS:0030764191
VL - 1997
SP - 949
EP - 952
JO - Synthesis
JF - Synthesis
SN - 0039-7881
IS - 8
ER -