Theoretical mechanisms in targeted and random integration of transgene DNA

Research output: Contribution to journalReview article

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Abstract

The genetic manipulation of mammalian cells and animals would be greatly expedited if gene targeting could be reliably achieved in the widest possible range of host cell types. This paper considers empirical evidence and theoretical considerations associated with transgene integration, and concludes that utilisation of gene targeting in non-selective systems awaits further progress in modelling homologous recombination.
Original languageEnglish
Pages (from-to)465-485
Number of pages21
JournalReproduction Nutrition Development
Volume41
Issue number6
DOIs
StatePublished - Dec 2001

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gene targeting
transgenes
cells
homologous recombination
genetic engineering
host range
DNA
animals

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Smith, Kevin R. / Theoretical mechanisms in targeted and random integration of transgene DNA.

In: Reproduction Nutrition Development, Vol. 41, No. 6, 12.2001, p. 465-485.

Research output: Contribution to journalReview article

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Theoretical mechanisms in targeted and random integration of transgene DNA. / Smith, Kevin R.

In: Reproduction Nutrition Development, Vol. 41, No. 6, 12.2001, p. 465-485.

Research output: Contribution to journalReview article

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