Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 465-485 |
| Number of pages | 21 |
| Journal | Reproduction Nutrition Development |
| Volume | 41 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2001 |
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Theoretical mechanisms in targeted and random integration of transgene DNA. / Smith, Kevin R.
In: Reproduction Nutrition Development, Vol. 41, No. 6, 12.2001, p. 465-485.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Theoretical mechanisms in targeted and random integration of transgene DNA
AU - Smith, Kevin R.
PY - 2001/12
Y1 - 2001/12
N2 - The genetic manipulation of mammalian cells and animals would be greatly expedited if gene targeting could be reliably achieved in the widest possible range of host cell types. This paper considers empirical evidence and theoretical considerations associated with transgene integration, and concludes that utilisation of gene targeting in non-selective systems awaits further progress in modelling homologous recombination.
AB - The genetic manipulation of mammalian cells and animals would be greatly expedited if gene targeting could be reliably achieved in the widest possible range of host cell types. This paper considers empirical evidence and theoretical considerations associated with transgene integration, and concludes that utilisation of gene targeting in non-selective systems awaits further progress in modelling homologous recombination.
U2 - 10.1051/rnd:2001102
DO - 10.1051/rnd:2001102
M3 - Review article
VL - 41
SP - 465
EP - 485
JO - Animal
JF - Animal
SN - 1751-7311
IS - 6
ER -