Theoretical mechanisms in targeted and random integration of transgene DNA

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    32 Citations (Scopus)

    Abstract

    The genetic manipulation of mammalian cells and animals would be greatly expedited if gene targeting could be reliably achieved in the widest possible range of host cell types. This paper considers empirical evidence and theoretical considerations associated with transgene integration, and concludes that utilisation of gene targeting in non-selective systems awaits further progress in modelling homologous recombination.
    Original languageEnglish
    Pages (from-to)465-485
    Number of pages21
    JournalReproduction Nutrition Development
    Volume41
    Issue number6
    DOIs
    Publication statusPublished - Dec 2001

    Keywords

    • Transgenesis
    • Gene targeting
    • Gene therapy
    • Integration
    • Homologous recombination
    • Concatenation

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