Theoretical mechanisms in targeted and random integration of transgene DNA

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The genetic manipulation of mammalian cells and animals would be greatly expedited if gene targeting could be reliably achieved in the widest possible range of host cell types. This paper considers empirical evidence and theoretical considerations associated with transgene integration, and concludes that utilisation of gene targeting in non-selective systems awaits further progress in modelling homologous recombination.
Original languageEnglish
Pages (from-to)465-485
Number of pages21
JournalReproduction Nutrition Development
Issue number6
Publication statusPublished - Dec 2001


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