Time course adaptations in oxygen uptake and muscle deoxygenation kinetics during submaximal exercise subsequent to a 12 week moderate-intensity continuous training or low-volume, high-intensity interval training intervention in type 2 diabetes.

Norita Gildea, Adam McDermott, Joel Rocha, Domenico Crognale, Aaron Nevin, Simon Green, Donal O'Shea, Mikel Egana

Research output: Contribution to conferenceAbstract

Abstract

The dynamic response of pulmonary oxygen uptake (τVO2) at the onset of moderate-intensity exercise is slowed in middle-aged individuals with type 2 diabetes (T2D) (O'Connor et al. 2012, 2015). This effect is attributed to progressive limitations of O2 delivery and/or utilisation. While traditional moderate-intensity continuous training (MICT) is an established strategy which enhances τVO2p (McAnaney et al. 2012), the effects of a time efficient low-volume, high-intensity interval training (LVHIIT) on τVO2p as well as the time course and mechanisms of adaptations of these enhanced VO2 kinetics following either MICT or LVHIIT are unknown. The aim of this study was to assess the rates of adjustment of VO2p and muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) during the on-transition to moderate-intensity cycling before training and at weeks 3, 6, 9 and 12 of MICT and LVHIIT. Twenty nine middle-aged individuals with T2D (17 men, 12 women; mean ± SD: age 53 ± 10 yr, body mass index 29.8 ± 4.4 kg.m-2) were randomly assigned to MICT (n=11, 50 min of moderate-intensity cycling) or LVHIIT (n=9, 10 x 1 min cycling at ~90% maximal heart rate interspersed by 1 min of ‘unloaded' cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week and every 3 weeks exercise intensity was adjusted. VO2 kinetics was calculated from continuously measured breath-by-breath VO2 data, whilst the rate of muscle deoxygenation was continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. Time point analysis of VO2 and [HHb+Mb] responses were performed using a two-way ANOVA with repeated-measures, and post-hoc Tukey tests performed when significant differences were returned. Pre-training τVO2p decreased (P<0.05) by a similar magnitude at wk 3 of training in both MICT (from 44 ± 12 to 32 ± 5 s) and LVHIIT (from 42 ± 8 to 32 ± 4 s) with no further changes thereafter. No changes were reported in the control group. The pretraining overall adjustment of Δ[HHb+Mb] was faster than τVO2p in all groups, resulting in Δ[HHb+Mb]/VO2p showing an "overshoot" during the transient relative to the subsequent steady-state level. After 3 wks of training the Δ[HHb+Mb]/VO2p overshoot was attenuated in both MICT and LVHIIT so that the overall adjustment of Δ[HHb+Mb] was similar to τVO2p in both groups. The enhanced VO2 kinetics response consequent to both MICT and LVHIIT in T2D is likely attributed to a training-induced better matching of O2 delivery to utilisation.
Original languageEnglish
Publication statusPublished - 14 Sep 2018
EventEurophysiology 2018 - QEII Centre, London, United Kingdom
Duration: 14 Sep 201816 Sep 2018
https://www.europhysiology2018.org/

Conference

ConferenceEurophysiology 2018
CountryUnited Kingdom
CityLondon
Period14/09/1816/09/18
Internet address

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Type 2 Diabetes Mellitus
Exercise
Oxygen
Muscles
Control Groups
Near-Infrared Spectroscopy
Myoglobin
Quadriceps Muscle
High-Intensity Interval Training
Analysis of Variance
Hemoglobins
Body Mass Index
Heart Rate
Lung

Cite this

Gildea, Norita ; McDermott, Adam ; Rocha, Joel ; Crognale, Domenico ; Nevin, Aaron ; Green, Simon ; O'Shea, Donal ; Egana, Mikel. / Time course adaptations in oxygen uptake and muscle deoxygenation kinetics during submaximal exercise subsequent to a 12 week moderate-intensity continuous training or low-volume, high-intensity interval training intervention in type 2 diabetes. Abstract from Europhysiology 2018, London, United Kingdom.
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title = "Time course adaptations in oxygen uptake and muscle deoxygenation kinetics during submaximal exercise subsequent to a 12 week moderate-intensity continuous training or low-volume, high-intensity interval training intervention in type 2 diabetes.",
abstract = "The dynamic response of pulmonary oxygen uptake (τVO2) at the onset of moderate-intensity exercise is slowed in middle-aged individuals with type 2 diabetes (T2D) (O'Connor et al. 2012, 2015). This effect is attributed to progressive limitations of O2 delivery and/or utilisation. While traditional moderate-intensity continuous training (MICT) is an established strategy which enhances τVO2p (McAnaney et al. 2012), the effects of a time efficient low-volume, high-intensity interval training (LVHIIT) on τVO2p as well as the time course and mechanisms of adaptations of these enhanced VO2 kinetics following either MICT or LVHIIT are unknown. The aim of this study was to assess the rates of adjustment of VO2p and muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) during the on-transition to moderate-intensity cycling before training and at weeks 3, 6, 9 and 12 of MICT and LVHIIT. Twenty nine middle-aged individuals with T2D (17 men, 12 women; mean ± SD: age 53 ± 10 yr, body mass index 29.8 ± 4.4 kg.m-2) were randomly assigned to MICT (n=11, 50 min of moderate-intensity cycling) or LVHIIT (n=9, 10 x 1 min cycling at ~90{\%} maximal heart rate interspersed by 1 min of ‘unloaded' cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week and every 3 weeks exercise intensity was adjusted. VO2 kinetics was calculated from continuously measured breath-by-breath VO2 data, whilst the rate of muscle deoxygenation was continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. Time point analysis of VO2 and [HHb+Mb] responses were performed using a two-way ANOVA with repeated-measures, and post-hoc Tukey tests performed when significant differences were returned. Pre-training τVO2p decreased (P<0.05) by a similar magnitude at wk 3 of training in both MICT (from 44 ± 12 to 32 ± 5 s) and LVHIIT (from 42 ± 8 to 32 ± 4 s) with no further changes thereafter. No changes were reported in the control group. The pretraining overall adjustment of Δ[HHb+Mb] was faster than τVO2p in all groups, resulting in Δ[HHb+Mb]/VO2p showing an {"}overshoot{"} during the transient relative to the subsequent steady-state level. After 3 wks of training the Δ[HHb+Mb]/VO2p overshoot was attenuated in both MICT and LVHIIT so that the overall adjustment of Δ[HHb+Mb] was similar to τVO2p in both groups. The enhanced VO2 kinetics response consequent to both MICT and LVHIIT in T2D is likely attributed to a training-induced better matching of O2 delivery to utilisation.",
author = "Norita Gildea and Adam McDermott and Joel Rocha and Domenico Crognale and Aaron Nevin and Simon Green and Donal O'Shea and Mikel Egana",
year = "2018",
month = "9",
day = "14",
language = "English",
note = "Europhysiology 2018 ; Conference date: 14-09-2018 Through 16-09-2018",
url = "https://www.europhysiology2018.org/",

}

Time course adaptations in oxygen uptake and muscle deoxygenation kinetics during submaximal exercise subsequent to a 12 week moderate-intensity continuous training or low-volume, high-intensity interval training intervention in type 2 diabetes. / Gildea, Norita; McDermott, Adam; Rocha, Joel; Crognale, Domenico; Nevin, Aaron; Green, Simon; O'Shea, Donal; Egana, Mikel.

2018. Abstract from Europhysiology 2018, London, United Kingdom.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Time course adaptations in oxygen uptake and muscle deoxygenation kinetics during submaximal exercise subsequent to a 12 week moderate-intensity continuous training or low-volume, high-intensity interval training intervention in type 2 diabetes.

AU - Gildea, Norita

AU - McDermott, Adam

AU - Rocha, Joel

AU - Crognale, Domenico

AU - Nevin, Aaron

AU - Green, Simon

AU - O'Shea, Donal

AU - Egana, Mikel

PY - 2018/9/14

Y1 - 2018/9/14

N2 - The dynamic response of pulmonary oxygen uptake (τVO2) at the onset of moderate-intensity exercise is slowed in middle-aged individuals with type 2 diabetes (T2D) (O'Connor et al. 2012, 2015). This effect is attributed to progressive limitations of O2 delivery and/or utilisation. While traditional moderate-intensity continuous training (MICT) is an established strategy which enhances τVO2p (McAnaney et al. 2012), the effects of a time efficient low-volume, high-intensity interval training (LVHIIT) on τVO2p as well as the time course and mechanisms of adaptations of these enhanced VO2 kinetics following either MICT or LVHIIT are unknown. The aim of this study was to assess the rates of adjustment of VO2p and muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) during the on-transition to moderate-intensity cycling before training and at weeks 3, 6, 9 and 12 of MICT and LVHIIT. Twenty nine middle-aged individuals with T2D (17 men, 12 women; mean ± SD: age 53 ± 10 yr, body mass index 29.8 ± 4.4 kg.m-2) were randomly assigned to MICT (n=11, 50 min of moderate-intensity cycling) or LVHIIT (n=9, 10 x 1 min cycling at ~90% maximal heart rate interspersed by 1 min of ‘unloaded' cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week and every 3 weeks exercise intensity was adjusted. VO2 kinetics was calculated from continuously measured breath-by-breath VO2 data, whilst the rate of muscle deoxygenation was continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. Time point analysis of VO2 and [HHb+Mb] responses were performed using a two-way ANOVA with repeated-measures, and post-hoc Tukey tests performed when significant differences were returned. Pre-training τVO2p decreased (P<0.05) by a similar magnitude at wk 3 of training in both MICT (from 44 ± 12 to 32 ± 5 s) and LVHIIT (from 42 ± 8 to 32 ± 4 s) with no further changes thereafter. No changes were reported in the control group. The pretraining overall adjustment of Δ[HHb+Mb] was faster than τVO2p in all groups, resulting in Δ[HHb+Mb]/VO2p showing an "overshoot" during the transient relative to the subsequent steady-state level. After 3 wks of training the Δ[HHb+Mb]/VO2p overshoot was attenuated in both MICT and LVHIIT so that the overall adjustment of Δ[HHb+Mb] was similar to τVO2p in both groups. The enhanced VO2 kinetics response consequent to both MICT and LVHIIT in T2D is likely attributed to a training-induced better matching of O2 delivery to utilisation.

AB - The dynamic response of pulmonary oxygen uptake (τVO2) at the onset of moderate-intensity exercise is slowed in middle-aged individuals with type 2 diabetes (T2D) (O'Connor et al. 2012, 2015). This effect is attributed to progressive limitations of O2 delivery and/or utilisation. While traditional moderate-intensity continuous training (MICT) is an established strategy which enhances τVO2p (McAnaney et al. 2012), the effects of a time efficient low-volume, high-intensity interval training (LVHIIT) on τVO2p as well as the time course and mechanisms of adaptations of these enhanced VO2 kinetics following either MICT or LVHIIT are unknown. The aim of this study was to assess the rates of adjustment of VO2p and muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) during the on-transition to moderate-intensity cycling before training and at weeks 3, 6, 9 and 12 of MICT and LVHIIT. Twenty nine middle-aged individuals with T2D (17 men, 12 women; mean ± SD: age 53 ± 10 yr, body mass index 29.8 ± 4.4 kg.m-2) were randomly assigned to MICT (n=11, 50 min of moderate-intensity cycling) or LVHIIT (n=9, 10 x 1 min cycling at ~90% maximal heart rate interspersed by 1 min of ‘unloaded' cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week and every 3 weeks exercise intensity was adjusted. VO2 kinetics was calculated from continuously measured breath-by-breath VO2 data, whilst the rate of muscle deoxygenation was continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. Time point analysis of VO2 and [HHb+Mb] responses were performed using a two-way ANOVA with repeated-measures, and post-hoc Tukey tests performed when significant differences were returned. Pre-training τVO2p decreased (P<0.05) by a similar magnitude at wk 3 of training in both MICT (from 44 ± 12 to 32 ± 5 s) and LVHIIT (from 42 ± 8 to 32 ± 4 s) with no further changes thereafter. No changes were reported in the control group. The pretraining overall adjustment of Δ[HHb+Mb] was faster than τVO2p in all groups, resulting in Δ[HHb+Mb]/VO2p showing an "overshoot" during the transient relative to the subsequent steady-state level. After 3 wks of training the Δ[HHb+Mb]/VO2p overshoot was attenuated in both MICT and LVHIIT so that the overall adjustment of Δ[HHb+Mb] was similar to τVO2p in both groups. The enhanced VO2 kinetics response consequent to both MICT and LVHIIT in T2D is likely attributed to a training-induced better matching of O2 delivery to utilisation.

M3 - Abstract

ER -