Time course adaptations in oxygen uptake kinetics during heavy-intensity exercise initiated from an elevated baseline subsequent to a 12 Week high-intensity interval or moderate-intensity continuous training in type 2 diabetes

Norita Gildea, Adam McDermott, Joel Rocha, Aaron Nevin, Donal O'Shea, Simon Green, Mikel Egana

Research output: Contribution to journalMeeting Abstract

Abstract

The dynamic response of pulmonary oxygen uptake (V̇O2) at the onset of heavy- intensity exercise initiated from an elevated baseline (work-to-work) is constrained in middle-aged individuals with uncomplicated type 2 diabetes (T2D) (Gildea et al. 2018b) attributed to progressive limitations of O2 delivery and/or utilization. Both low-volume, high-intensity interval training (LVHIIT) and moderate-intensity continuous training (MICT) have been shown to be effective at accelerating V̇O2 kinetics during stepwise transitions from rest to moderate- (Gildea et al. 2018a), and heavy-intensity exercise (Nevin et al. 2018) in middle-aged individuals with T2D. However, the effects of such protocols on V̇O2 kinetics during heavy-intensity work-to-work cycling in individuals with T2D are unknown. Purpose: To assess the rates of adjustment of V̇O2p and muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) during the on-transition to heavy-intensity work-to-work cycling before training and at weeks 3, 6, 9 and 12 of MICT and LVHIIT. Methods: Twenty eight middle-aged individuals with T2D (17 men, 11 women; mean ± SD; age: 53 ± 10 yr, body mass index: 29.8 ± 4.4 kg.m-2) were randomly assigned to MICT (n=11, 50 min of moderate-intensity cycling), LVHIIT (n=8, 10 x 1 min cycling at ~90% maximal heart rate interspersed by 1 min of ‘unloaded’ cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week with intensity adjusted every 3 weeks. V̇O2 kinetics was calculated from continuously measured breath-by-breath V̇O2 data, and the rate of muscle deoxygenation continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. Time point analysis of V̇O2 and [HHb+Mb] responses were performed using a two-way ANOVA with repeated-measures, and Tukey post-hoc tests performed when significant differences presented. Results: The pre-training time constant of the V̇O2 primary phase (τV̇O2P), the amplitude of the V̇O2 slow component (V̇O2scA) and V̇O2 mean response time (MRT), decreased (P<0.05) by a similar magnitude at wk 3 of training in both the MICT (48±10 to 30±8 s; 0.18±0.08 to 0.10±0.05 L.min-1 and 80±19 to 61±13 s, respectively) and LVHIIT (43±13 to 27±6 s; 0.20±0.07 to 0.14±0.06 L.min-1 and 73±17 to 60±13 s, respectively) groups with no further changes thereafter. No changes were reported in the control group. The pre-training parameter estimates of Δ[HHb+Mb] remained unchanged throughout the interventions. Conclusion: The enhanced V̇O2 kinetics responses during work-to-work transitions consequent to both MICT and LVHIIT in T2D is likely attributed to a combination of training-induced changes in skeletal muscle properties, motor unit recruitment patterns and improvements in O2 delivery relative to utilization during exercise.
Original languageEnglish
Article number830.8
JournalFASEB Journal
Volume33
Issue number1 Suppl.
Publication statusPublished - 1 Apr 2019
EventExperimental Biology 2019 - Orange County Convention Center, Orlando, United States
Duration: 6 Apr 20199 Apr 2019
https://experimentalbiology.org/2019/About/About-Experimental-Biology.aspx

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Medical problems
Type 2 Diabetes Mellitus
Exercise
Muscle
Oxygen
Kinetics
Near infrared spectroscopy
Muscles
Myoglobin
Analysis of variance (ANOVA)
Neurophysiological Recruitment
Dynamic response
Social Adjustment
Hemoglobins
Control Groups
Near-Infrared Spectroscopy
Quadriceps Muscle
Reaction Time
Analysis of Variance
Skeletal Muscle

Cite this

@article{1f1189f2752d4a19981f7efc24f35c09,
title = "Time course adaptations in oxygen uptake kinetics during heavy-intensity exercise initiated from an elevated baseline subsequent to a 12 Week high-intensity interval or moderate-intensity continuous training in type 2 diabetes",
abstract = "The dynamic response of pulmonary oxygen uptake (V̇O2) at the onset of heavy- intensity exercise initiated from an elevated baseline (work-to-work) is constrained in middle-aged individuals with uncomplicated type 2 diabetes (T2D) (Gildea et al. 2018b) attributed to progressive limitations of O2 delivery and/or utilization. Both low-volume, high-intensity interval training (LVHIIT) and moderate-intensity continuous training (MICT) have been shown to be effective at accelerating V̇O2 kinetics during stepwise transitions from rest to moderate- (Gildea et al. 2018a), and heavy-intensity exercise (Nevin et al. 2018) in middle-aged individuals with T2D. However, the effects of such protocols on V̇O2 kinetics during heavy-intensity work-to-work cycling in individuals with T2D are unknown. Purpose: To assess the rates of adjustment of V̇O2p and muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) during the on-transition to heavy-intensity work-to-work cycling before training and at weeks 3, 6, 9 and 12 of MICT and LVHIIT. Methods: Twenty eight middle-aged individuals with T2D (17 men, 11 women; mean ± SD; age: 53 ± 10 yr, body mass index: 29.8 ± 4.4 kg.m-2) were randomly assigned to MICT (n=11, 50 min of moderate-intensity cycling), LVHIIT (n=8, 10 x 1 min cycling at ~90{\%} maximal heart rate interspersed by 1 min of ‘unloaded’ cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week with intensity adjusted every 3 weeks. V̇O2 kinetics was calculated from continuously measured breath-by-breath V̇O2 data, and the rate of muscle deoxygenation continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. Time point analysis of V̇O2 and [HHb+Mb] responses were performed using a two-way ANOVA with repeated-measures, and Tukey post-hoc tests performed when significant differences presented. Results: The pre-training time constant of the V̇O2 primary phase (τV̇O2P), the amplitude of the V̇O2 slow component (V̇O2scA) and V̇O2 mean response time (MRT), decreased (P<0.05) by a similar magnitude at wk 3 of training in both the MICT (48±10 to 30±8 s; 0.18±0.08 to 0.10±0.05 L.min-1 and 80±19 to 61±13 s, respectively) and LVHIIT (43±13 to 27±6 s; 0.20±0.07 to 0.14±0.06 L.min-1 and 73±17 to 60±13 s, respectively) groups with no further changes thereafter. No changes were reported in the control group. The pre-training parameter estimates of Δ[HHb+Mb] remained unchanged throughout the interventions. Conclusion: The enhanced V̇O2 kinetics responses during work-to-work transitions consequent to both MICT and LVHIIT in T2D is likely attributed to a combination of training-induced changes in skeletal muscle properties, motor unit recruitment patterns and improvements in O2 delivery relative to utilization during exercise.",
author = "Norita Gildea and Adam McDermott and Joel Rocha and Aaron Nevin and Donal O'Shea and Simon Green and Mikel Egana",
year = "2019",
month = "4",
day = "1",
language = "English",
volume = "33",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "1 Suppl.",

}

Time course adaptations in oxygen uptake kinetics during heavy-intensity exercise initiated from an elevated baseline subsequent to a 12 Week high-intensity interval or moderate-intensity continuous training in type 2 diabetes. / Gildea, Norita; McDermott, Adam; Rocha, Joel; Nevin, Aaron; O'Shea, Donal; Green, Simon; Egana, Mikel.

In: FASEB Journal, Vol. 33, No. 1 Suppl., 830.8, 01.04.2019.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Time course adaptations in oxygen uptake kinetics during heavy-intensity exercise initiated from an elevated baseline subsequent to a 12 Week high-intensity interval or moderate-intensity continuous training in type 2 diabetes

AU - Gildea, Norita

AU - McDermott, Adam

AU - Rocha, Joel

AU - Nevin, Aaron

AU - O'Shea, Donal

AU - Green, Simon

AU - Egana, Mikel

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The dynamic response of pulmonary oxygen uptake (V̇O2) at the onset of heavy- intensity exercise initiated from an elevated baseline (work-to-work) is constrained in middle-aged individuals with uncomplicated type 2 diabetes (T2D) (Gildea et al. 2018b) attributed to progressive limitations of O2 delivery and/or utilization. Both low-volume, high-intensity interval training (LVHIIT) and moderate-intensity continuous training (MICT) have been shown to be effective at accelerating V̇O2 kinetics during stepwise transitions from rest to moderate- (Gildea et al. 2018a), and heavy-intensity exercise (Nevin et al. 2018) in middle-aged individuals with T2D. However, the effects of such protocols on V̇O2 kinetics during heavy-intensity work-to-work cycling in individuals with T2D are unknown. Purpose: To assess the rates of adjustment of V̇O2p and muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) during the on-transition to heavy-intensity work-to-work cycling before training and at weeks 3, 6, 9 and 12 of MICT and LVHIIT. Methods: Twenty eight middle-aged individuals with T2D (17 men, 11 women; mean ± SD; age: 53 ± 10 yr, body mass index: 29.8 ± 4.4 kg.m-2) were randomly assigned to MICT (n=11, 50 min of moderate-intensity cycling), LVHIIT (n=8, 10 x 1 min cycling at ~90% maximal heart rate interspersed by 1 min of ‘unloaded’ cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week with intensity adjusted every 3 weeks. V̇O2 kinetics was calculated from continuously measured breath-by-breath V̇O2 data, and the rate of muscle deoxygenation continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. Time point analysis of V̇O2 and [HHb+Mb] responses were performed using a two-way ANOVA with repeated-measures, and Tukey post-hoc tests performed when significant differences presented. Results: The pre-training time constant of the V̇O2 primary phase (τV̇O2P), the amplitude of the V̇O2 slow component (V̇O2scA) and V̇O2 mean response time (MRT), decreased (P<0.05) by a similar magnitude at wk 3 of training in both the MICT (48±10 to 30±8 s; 0.18±0.08 to 0.10±0.05 L.min-1 and 80±19 to 61±13 s, respectively) and LVHIIT (43±13 to 27±6 s; 0.20±0.07 to 0.14±0.06 L.min-1 and 73±17 to 60±13 s, respectively) groups with no further changes thereafter. No changes were reported in the control group. The pre-training parameter estimates of Δ[HHb+Mb] remained unchanged throughout the interventions. Conclusion: The enhanced V̇O2 kinetics responses during work-to-work transitions consequent to both MICT and LVHIIT in T2D is likely attributed to a combination of training-induced changes in skeletal muscle properties, motor unit recruitment patterns and improvements in O2 delivery relative to utilization during exercise.

AB - The dynamic response of pulmonary oxygen uptake (V̇O2) at the onset of heavy- intensity exercise initiated from an elevated baseline (work-to-work) is constrained in middle-aged individuals with uncomplicated type 2 diabetes (T2D) (Gildea et al. 2018b) attributed to progressive limitations of O2 delivery and/or utilization. Both low-volume, high-intensity interval training (LVHIIT) and moderate-intensity continuous training (MICT) have been shown to be effective at accelerating V̇O2 kinetics during stepwise transitions from rest to moderate- (Gildea et al. 2018a), and heavy-intensity exercise (Nevin et al. 2018) in middle-aged individuals with T2D. However, the effects of such protocols on V̇O2 kinetics during heavy-intensity work-to-work cycling in individuals with T2D are unknown. Purpose: To assess the rates of adjustment of V̇O2p and muscle deoxygenation (i.e., deoxygenated haemoglobin and myoglobin, [HHb+Mb]) during the on-transition to heavy-intensity work-to-work cycling before training and at weeks 3, 6, 9 and 12 of MICT and LVHIIT. Methods: Twenty eight middle-aged individuals with T2D (17 men, 11 women; mean ± SD; age: 53 ± 10 yr, body mass index: 29.8 ± 4.4 kg.m-2) were randomly assigned to MICT (n=11, 50 min of moderate-intensity cycling), LVHIIT (n=8, 10 x 1 min cycling at ~90% maximal heart rate interspersed by 1 min of ‘unloaded’ cycling) or to a non-exercising control group (n=9). Exercising groups trained 3 times/week with intensity adjusted every 3 weeks. V̇O2 kinetics was calculated from continuously measured breath-by-breath V̇O2 data, and the rate of muscle deoxygenation continuously measured by near-infrared spectroscopy at the vastus lateralis muscle. Time point analysis of V̇O2 and [HHb+Mb] responses were performed using a two-way ANOVA with repeated-measures, and Tukey post-hoc tests performed when significant differences presented. Results: The pre-training time constant of the V̇O2 primary phase (τV̇O2P), the amplitude of the V̇O2 slow component (V̇O2scA) and V̇O2 mean response time (MRT), decreased (P<0.05) by a similar magnitude at wk 3 of training in both the MICT (48±10 to 30±8 s; 0.18±0.08 to 0.10±0.05 L.min-1 and 80±19 to 61±13 s, respectively) and LVHIIT (43±13 to 27±6 s; 0.20±0.07 to 0.14±0.06 L.min-1 and 73±17 to 60±13 s, respectively) groups with no further changes thereafter. No changes were reported in the control group. The pre-training parameter estimates of Δ[HHb+Mb] remained unchanged throughout the interventions. Conclusion: The enhanced V̇O2 kinetics responses during work-to-work transitions consequent to both MICT and LVHIIT in T2D is likely attributed to a combination of training-induced changes in skeletal muscle properties, motor unit recruitment patterns and improvements in O2 delivery relative to utilization during exercise.

M3 - Meeting Abstract

VL - 33

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 1 Suppl.

M1 - 830.8

ER -