Triclosan – an update

S. Saleh; R. N. S. Haddadin; S. Baillie; Phillip J. Collier

doi:10.1111/j.1472-765X.2010.02976.x

Triclosan – an update

S. Saleh, R. N. S. Haddadin, S. Baillie, Phillip J. Collier

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Abstract

The discovery in 1998 that triclosan has a site-specific action in the bacterial cell as an inhibitor of NADH- or NADPH-dependent enoyl-acyl carrier protein reductase led to a lively debate in the scientific press. The thesis of this debate was that such a mode of action may allow triclosan to induce resistance and cross-resistance in bacterial cells. The debate last saw review in 2004, and this paper aims at updating our knowledge in this area, given recent research on the topic.

Original language	English
Pages (from-to)	87-95
Number of pages	9
Journal	Letters in Applied Microbiology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1111/j.1472-765X.2010.02976.x
Publication status	Published - Feb 2011

Keywords

Antibiotics
Biocides
Mechanism of action
Resistance
Antimicrobials

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10.1111/j.1472-765X.2010.02976.x

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abstract = "The discovery in 1998 that triclosan has a site-specific action in the bacterial cell as an inhibitor of NADH- or NADPH-dependent enoyl-acyl carrier protein reductase led to a lively debate in the scientific press. The thesis of this debate was that such a mode of action may allow triclosan to induce resistance and cross-resistance in bacterial cells. The debate last saw review in 2004, and this paper aims at updating our knowledge in this area, given recent research on the topic.",

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AB - The discovery in 1998 that triclosan has a site-specific action in the bacterial cell as an inhibitor of NADH- or NADPH-dependent enoyl-acyl carrier protein reductase led to a lively debate in the scientific press. The thesis of this debate was that such a mode of action may allow triclosan to induce resistance and cross-resistance in bacterial cells. The debate last saw review in 2004, and this paper aims at updating our knowledge in this area, given recent research on the topic.

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Triclosan – an update

Abstract

Keywords

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