Tyrosine dephosphorylation underlies DHPG-induced LTD

Peter R. Moult; Rebecca Schnabel; Ian C. Kilpatrick; Zafar I. Bashir; Graham L. Collingridge

doi:10.1016/S0028-3908(02)00110-7

Tyrosine dephosphorylation underlies DHPG-induced LTD

Peter R. Moult, Rebecca Schnabel, Ian C. Kilpatrick, Zafar I. Bashir, Graham L. Collingridge

Abertay University

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

A form of long-term depression (LTD) of synaptic transmission can be induced by bath application of the group I metabotropic glutamate (mGlu) receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). The mechanisms responsible for the induction and expression of DHPG-induced LTD in the CA1 region of the hippocampus are currently the subject of intense investigation. Here we show that two protein tyrosine kinase (PTK) inhibitors (10 μM lavendustin A or 30 μM genistein) have little effect on DHPG-induced LTD. In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 μM phenyl–arsine oxide) significantly inhibited DHPG-induced LTD. These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase.

Original language	English
Pages (from-to)	175-180
Number of pages	6
Journal	Neuropharmacology
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/S0028-3908(02)00110-7
Publication status	Published - Aug 2002

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title = "Tyrosine dephosphorylation underlies DHPG-induced LTD",

abstract = "A form of long-term depression (LTD) of synaptic transmission can be induced by bath application of the group I metabotropic glutamate (mGlu) receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). The mechanisms responsible for the induction and expression of DHPG-induced LTD in the CA1 region of the hippocampus are currently the subject of intense investigation. Here we show that two protein tyrosine kinase (PTK) inhibitors (10 μM lavendustin A or 30 μM genistein) have little effect on DHPG-induced LTD. In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 μM phenyl–arsine oxide) significantly inhibited DHPG-induced LTD. These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase.",

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AU - Moult, Peter R.

AU - Schnabel, Rebecca

AU - Kilpatrick, Ian C.

AU - Bashir, Zafar I.

AU - Collingridge, Graham L.

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