Tyrosine dephosphorylation underlies DHPG-induced LTD

Peter R. Moult; Rebecca Schnabel; Ian C. Kilpatrick; Zafar I. Bashir; Graham L. Collingridge

doi:10.1016/S0028-3908(02)00110-7

Tyrosine dephosphorylation underlies DHPG-induced LTD

Peter R. Moult, Rebecca Schnabel, Ian C. Kilpatrick, Zafar I. Bashir, Graham L. Collingridge

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

A form of long-term depression (LTD) of synaptic transmission can be induced by bath application of the group I metabotropic glutamate (mGlu) receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). The mechanisms responsible for the induction and expression of DHPG-induced LTD in the CA1 region of the hippocampus are currently the subject of intense investigation. Here we show that two protein tyrosine kinase (PTK) inhibitors (10 μM lavendustin A or 30 μM genistein) have little effect on DHPG-induced LTD. In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 μM phenyl–arsine oxide) significantly inhibited DHPG-induced LTD. These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase.

Original language	English
Pages (from-to)	175-180
Number of pages	6
Journal	Neuropharmacology
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/S0028-3908(02)00110-7
Publication status	Published - Aug 2002
Externally published	Yes

Keywords

Tyrosine
PTK
PTP
Glutamate receptor
Synaptic plasticity
LTD
DHPG
mGlu

Access to Document

10.1016/S0028-3908(02)00110-7

Cite this

@article{1fdd52f8babb4979bc44140d709c8c92,

title = "Tyrosine dephosphorylation underlies DHPG-induced LTD",

abstract = "A form of long-term depression (LTD) of synaptic transmission can be induced by bath application of the group I metabotropic glutamate (mGlu) receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). The mechanisms responsible for the induction and expression of DHPG-induced LTD in the CA1 region of the hippocampus are currently the subject of intense investigation. Here we show that two protein tyrosine kinase (PTK) inhibitors (10 μM lavendustin A or 30 μM genistein) have little effect on DHPG-induced LTD. In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 μM phenyl–arsine oxide) significantly inhibited DHPG-induced LTD. These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase.",

author = "Moult, \{Peter R.\} and Rebecca Schnabel and Kilpatrick, \{Ian C.\} and Bashir, \{Zafar I.\} and Collingridge, \{Graham L.\}",

year = "2002",

month = aug,

doi = "10.1016/S0028-3908(02)00110-7",

language = "English",

volume = "43",

pages = "175--180",

journal = "Neuropharmacology",

issn = "1873-7064",

publisher = "Elsevier Ltd",

number = "2",

}

TY - JOUR

T1 - Tyrosine dephosphorylation underlies DHPG-induced LTD

AU - Moult, Peter R.

AU - Schnabel, Rebecca

AU - Kilpatrick, Ian C.

AU - Bashir, Zafar I.

AU - Collingridge, Graham L.

PY - 2002/8

Y1 - 2002/8

N2 - A form of long-term depression (LTD) of synaptic transmission can be induced by bath application of the group I metabotropic glutamate (mGlu) receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). The mechanisms responsible for the induction and expression of DHPG-induced LTD in the CA1 region of the hippocampus are currently the subject of intense investigation. Here we show that two protein tyrosine kinase (PTK) inhibitors (10 μM lavendustin A or 30 μM genistein) have little effect on DHPG-induced LTD. In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 μM phenyl–arsine oxide) significantly inhibited DHPG-induced LTD. These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase.

AB - A form of long-term depression (LTD) of synaptic transmission can be induced by bath application of the group I metabotropic glutamate (mGlu) receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). The mechanisms responsible for the induction and expression of DHPG-induced LTD in the CA1 region of the hippocampus are currently the subject of intense investigation. Here we show that two protein tyrosine kinase (PTK) inhibitors (10 μM lavendustin A or 30 μM genistein) have little effect on DHPG-induced LTD. In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 μM phenyl–arsine oxide) significantly inhibited DHPG-induced LTD. These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase.

U2 - 10.1016/S0028-3908(02)00110-7

DO - 10.1016/S0028-3908(02)00110-7

M3 - Article

SN - 1873-7064

VL - 43

SP - 175

EP - 180

JO - Neuropharmacology

JF - Neuropharmacology

IS - 2

ER -

Tyrosine dephosphorylation underlies DHPG-induced LTD

Abstract

Keywords

Access to Document

Fingerprint

Cite this