Vitamin K to improve markers of vascular health and physical function in older people with vascular disease: a randomised controlled trial

Roberta Fulton, M E T McMurdo, A Hill, R J Abboud, G P Arnold, A D Struthers, F Khan, M D Witham

Research output: Contribution to journalMeeting Abstract

Abstract

Introduction: Low vitamin K intake has been linked to impaired muscle function, osteoporosis, stiffer arteries and an increased risk of cardiovascular disease. We investigated whether supplementation with vitamin K exerted beneficial effects on vascular health and physical function in older people with established vascular disease. 
Methods: We recruited community based participants aged ≥70 years, with a history of hypertension, diabetes mellitus or a previous vascular event, to a double blind randomised controlled trial comparing the effect of 6 months of daily oral 100 mcg vitamin K2 or placebo. Outcomes were measured at 0, 3 & 6 months. Primary outcome was between-group difference endothelial function assessed using flow-mediated dilatation of the brachial artery. Secondary vascular outcomes were carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type Natriuretic Peptide and cholesterol. Handgrip strength and Short Physical Performance Battery were used to assess physical function. Postural sway was measured using forceplate analysis assessed over 30 seconds.
Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 (55%) were male. No change was seen in the primary outcome of endothelial function (between group difference −0.3% [95%CI −1.3 to 0.8], p = 0.62). A modest, but non-significant improvement in arterial stiffness was seen in the vitamin K group compared to placebo (−0.8m/s [95%CI −1.8 to 0.3], p = 0.15) with all other vascular outcomes unchanged. A non-significant improvement was seen in mediolateral sway with vitamin K compared to placebo (-3.1mm [95%CI −9.0 to 2.8], p = 0.30).
Conclusions: Vitamin K supplementation did not improve markers of vascular health or physical function in this trial. The non-significant improvements in arterial stiffness and sway require further study.
Original languageEnglish
Article number50
Pages (from-to)ii14
Number of pages1
JournalAge and Ageing
Volume43
Issue numbersuppl_2
DOIs
Publication statusPublished - 1 Oct 2014
Externally publishedYes
EventBritish Geriatrics Society Spring Meeting 2014 - Manchester University, Manchester, United Kingdom
Duration: 23 Apr 201425 Apr 2014
https://www.eiseverywhere.com/ehome/bgsspring2014/164171/

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Vitamin K
Vascular Diseases
Blood Vessels
Randomized Controlled Trials
Health
Vascular Stiffness
Placebos
Vitamin K 2
Carotid Intima-Media Thickness
Pulse Wave Analysis
Brachial Artery
Brain Natriuretic Peptide
C-Reactive Protein
Osteoporosis
Dilatation
Diabetes Mellitus
Cardiovascular Diseases
Arteries
Cholesterol
Blood Pressure

Cite this

Fulton, R., McMurdo, M. E. T., Hill, A., Abboud, R. J., Arnold, G. P., Struthers, A. D., ... Witham, M. D. (2014). Vitamin K to improve markers of vascular health and physical function in older people with vascular disease: a randomised controlled trial. Age and Ageing, 43(suppl_2), ii14. [50]. https://doi.org/10.1093/ageing/afu127.2
Fulton, Roberta ; McMurdo, M E T ; Hill, A ; Abboud, R J ; Arnold, G P ; Struthers, A D ; Khan, F ; Witham, M D. / Vitamin K to improve markers of vascular health and physical function in older people with vascular disease : a randomised controlled trial. In: Age and Ageing. 2014 ; Vol. 43, No. suppl_2. pp. ii14.
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title = "Vitamin K to improve markers of vascular health and physical function in older people with vascular disease: a randomised controlled trial",
abstract = "Introduction: Low vitamin K intake has been linked to impaired muscle function, osteoporosis, stiffer arteries and an increased risk of cardiovascular disease. We investigated whether supplementation with vitamin K exerted beneficial effects on vascular health and physical function in older people with established vascular disease. Methods: We recruited community based participants aged ≥70 years, with a history of hypertension, diabetes mellitus or a previous vascular event, to a double blind randomised controlled trial comparing the effect of 6 months of daily oral 100 mcg vitamin K2 or placebo. Outcomes were measured at 0, 3 & 6 months. Primary outcome was between-group difference endothelial function assessed using flow-mediated dilatation of the brachial artery. Secondary vascular outcomes were carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type Natriuretic Peptide and cholesterol. Handgrip strength and Short Physical Performance Battery were used to assess physical function. Postural sway was measured using forceplate analysis assessed over 30 seconds.Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 (55{\%}) were male. No change was seen in the primary outcome of endothelial function (between group difference −0.3{\%} [95{\%}CI −1.3 to 0.8], p = 0.62). A modest, but non-significant improvement in arterial stiffness was seen in the vitamin K group compared to placebo (−0.8m/s [95{\%}CI −1.8 to 0.3], p = 0.15) with all other vascular outcomes unchanged. A non-significant improvement was seen in mediolateral sway with vitamin K compared to placebo (-3.1mm [95{\%}CI −9.0 to 2.8], p = 0.30).Conclusions: Vitamin K supplementation did not improve markers of vascular health or physical function in this trial. The non-significant improvements in arterial stiffness and sway require further study.",
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Fulton, R, McMurdo, MET, Hill, A, Abboud, RJ, Arnold, GP, Struthers, AD, Khan, F & Witham, MD 2014, 'Vitamin K to improve markers of vascular health and physical function in older people with vascular disease: a randomised controlled trial', Age and Ageing, vol. 43, no. suppl_2, 50, pp. ii14. https://doi.org/10.1093/ageing/afu127.2

Vitamin K to improve markers of vascular health and physical function in older people with vascular disease : a randomised controlled trial. / Fulton, Roberta; McMurdo, M E T; Hill, A; Abboud, R J; Arnold, G P; Struthers, A D; Khan, F; Witham, M D.

In: Age and Ageing, Vol. 43, No. suppl_2, 50, 01.10.2014, p. ii14.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Vitamin K to improve markers of vascular health and physical function in older people with vascular disease

T2 - a randomised controlled trial

AU - Fulton, Roberta

AU - McMurdo, M E T

AU - Hill, A

AU - Abboud, R J

AU - Arnold, G P

AU - Struthers, A D

AU - Khan, F

AU - Witham, M D

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Introduction: Low vitamin K intake has been linked to impaired muscle function, osteoporosis, stiffer arteries and an increased risk of cardiovascular disease. We investigated whether supplementation with vitamin K exerted beneficial effects on vascular health and physical function in older people with established vascular disease. Methods: We recruited community based participants aged ≥70 years, with a history of hypertension, diabetes mellitus or a previous vascular event, to a double blind randomised controlled trial comparing the effect of 6 months of daily oral 100 mcg vitamin K2 or placebo. Outcomes were measured at 0, 3 & 6 months. Primary outcome was between-group difference endothelial function assessed using flow-mediated dilatation of the brachial artery. Secondary vascular outcomes were carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type Natriuretic Peptide and cholesterol. Handgrip strength and Short Physical Performance Battery were used to assess physical function. Postural sway was measured using forceplate analysis assessed over 30 seconds.Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 (55%) were male. No change was seen in the primary outcome of endothelial function (between group difference −0.3% [95%CI −1.3 to 0.8], p = 0.62). A modest, but non-significant improvement in arterial stiffness was seen in the vitamin K group compared to placebo (−0.8m/s [95%CI −1.8 to 0.3], p = 0.15) with all other vascular outcomes unchanged. A non-significant improvement was seen in mediolateral sway with vitamin K compared to placebo (-3.1mm [95%CI −9.0 to 2.8], p = 0.30).Conclusions: Vitamin K supplementation did not improve markers of vascular health or physical function in this trial. The non-significant improvements in arterial stiffness and sway require further study.

AB - Introduction: Low vitamin K intake has been linked to impaired muscle function, osteoporosis, stiffer arteries and an increased risk of cardiovascular disease. We investigated whether supplementation with vitamin K exerted beneficial effects on vascular health and physical function in older people with established vascular disease. Methods: We recruited community based participants aged ≥70 years, with a history of hypertension, diabetes mellitus or a previous vascular event, to a double blind randomised controlled trial comparing the effect of 6 months of daily oral 100 mcg vitamin K2 or placebo. Outcomes were measured at 0, 3 & 6 months. Primary outcome was between-group difference endothelial function assessed using flow-mediated dilatation of the brachial artery. Secondary vascular outcomes were carotid-radial pulse wave velocity, augmentation index, blood pressure, carotid intima-media thickness, C-reactive protein, B-type Natriuretic Peptide and cholesterol. Handgrip strength and Short Physical Performance Battery were used to assess physical function. Postural sway was measured using forceplate analysis assessed over 30 seconds.Results: 80 participants were randomised, mean age 77 (SD 5) years; 44/80 (55%) were male. No change was seen in the primary outcome of endothelial function (between group difference −0.3% [95%CI −1.3 to 0.8], p = 0.62). A modest, but non-significant improvement in arterial stiffness was seen in the vitamin K group compared to placebo (−0.8m/s [95%CI −1.8 to 0.3], p = 0.15) with all other vascular outcomes unchanged. A non-significant improvement was seen in mediolateral sway with vitamin K compared to placebo (-3.1mm [95%CI −9.0 to 2.8], p = 0.30).Conclusions: Vitamin K supplementation did not improve markers of vascular health or physical function in this trial. The non-significant improvements in arterial stiffness and sway require further study.

U2 - 10.1093/ageing/afu127.2

DO - 10.1093/ageing/afu127.2

M3 - Meeting Abstract

VL - 43

SP - ii14

JO - Age and Ageing

JF - Age and Ageing

SN - 0002-0729

IS - suppl_2

M1 - 50

ER -