Weight change in adult life and health outcomes

Alison M Elliott, Lorna S Aucott, Philip C Hannaford, W Cairns Smith

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the relationship between weight change in adult life and subsequent mortality and cancer incidence in women.

RESEARCH METHODS AND PROCEDURES: In 1994 to 1995, all women (age range, 42 to 81) still under general practitioner observation in the United Kingdom's Royal College of General Practitioners Oral Contraception Study (n = 12,303) were sent a health survey asking about health and lifestyle issues, including current weight and weight at age 30. The main outcome measures were 6-year all-cause mortality and cancer incidence among different weight change deciles. Cox regression was used to calculate hazard ratios that were adjusted for: social class at recruitment, BMI at age 30, and age group, parity, smoking status, and hormone replacement therapy status in 1995.

RESULTS: Women who had been obese at age 30 were more likely to die and significantly more likely to develop cancer in the 6 years after the health survey than non-obese respondents. Women reporting weight gains between age 30 and 1995 were significantly less likely to die during the 6 years after the health survey than those with a stable weight, whereas those with weight loss did not fare any better than those in the stable-weight group.

DISCUSSION: Although obesity at young age was associated with subsequent mortality and cancer incidence, weight gain over a time period of 12 to 51 years appeared to be beneficial when compared with women with stable weight over the same time period. Further research is needed to confirm or refute our findings and to allow detailed examination of potential explanations for them.

Original languageEnglish
Pages (from-to)1784-1792
Number of pages9
JournalObesity
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 2005
Externally publishedYes

Fingerprint

Weights and Measures
Health
Health Surveys
General Practitioners
Weight Gain
Mortality
Neoplasms
Incidence
Hormone Replacement Therapy
Parity
Contraception
Research
Social Class
Life Style
Weight Loss
Age Groups
Obesity
Smoking
Observation
Outcome Assessment (Health Care)

Cite this

Elliott, A. M., Aucott, L. S., Hannaford, P. C., & Smith, W. C. (2005). Weight change in adult life and health outcomes. Obesity, 13(10), 1784-1792. https://doi.org/10.1038/oby.2005.217
Elliott, Alison M ; Aucott, Lorna S ; Hannaford, Philip C ; Smith, W Cairns. / Weight change in adult life and health outcomes. In: Obesity. 2005 ; Vol. 13, No. 10. pp. 1784-1792.
@article{3c6229ca82344b7d847b33742607a402,
title = "Weight change in adult life and health outcomes",
abstract = "OBJECTIVE: To investigate the relationship between weight change in adult life and subsequent mortality and cancer incidence in women.RESEARCH METHODS AND PROCEDURES: In 1994 to 1995, all women (age range, 42 to 81) still under general practitioner observation in the United Kingdom's Royal College of General Practitioners Oral Contraception Study (n = 12,303) were sent a health survey asking about health and lifestyle issues, including current weight and weight at age 30. The main outcome measures were 6-year all-cause mortality and cancer incidence among different weight change deciles. Cox regression was used to calculate hazard ratios that were adjusted for: social class at recruitment, BMI at age 30, and age group, parity, smoking status, and hormone replacement therapy status in 1995.RESULTS: Women who had been obese at age 30 were more likely to die and significantly more likely to develop cancer in the 6 years after the health survey than non-obese respondents. Women reporting weight gains between age 30 and 1995 were significantly less likely to die during the 6 years after the health survey than those with a stable weight, whereas those with weight loss did not fare any better than those in the stable-weight group.DISCUSSION: Although obesity at young age was associated with subsequent mortality and cancer incidence, weight gain over a time period of 12 to 51 years appeared to be beneficial when compared with women with stable weight over the same time period. Further research is needed to confirm or refute our findings and to allow detailed examination of potential explanations for them.",
author = "Elliott, {Alison M} and Aucott, {Lorna S} and Hannaford, {Philip C} and Smith, {W Cairns}",
year = "2005",
month = "10",
doi = "10.1038/oby.2005.217",
language = "English",
volume = "13",
pages = "1784--1792",
journal = "Obesity Research",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "10",

}

Elliott, AM, Aucott, LS, Hannaford, PC & Smith, WC 2005, 'Weight change in adult life and health outcomes', Obesity, vol. 13, no. 10, pp. 1784-1792. https://doi.org/10.1038/oby.2005.217

Weight change in adult life and health outcomes. / Elliott, Alison M; Aucott, Lorna S; Hannaford, Philip C; Smith, W Cairns.

In: Obesity, Vol. 13, No. 10, 10.2005, p. 1784-1792.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Weight change in adult life and health outcomes

AU - Elliott, Alison M

AU - Aucott, Lorna S

AU - Hannaford, Philip C

AU - Smith, W Cairns

PY - 2005/10

Y1 - 2005/10

N2 - OBJECTIVE: To investigate the relationship between weight change in adult life and subsequent mortality and cancer incidence in women.RESEARCH METHODS AND PROCEDURES: In 1994 to 1995, all women (age range, 42 to 81) still under general practitioner observation in the United Kingdom's Royal College of General Practitioners Oral Contraception Study (n = 12,303) were sent a health survey asking about health and lifestyle issues, including current weight and weight at age 30. The main outcome measures were 6-year all-cause mortality and cancer incidence among different weight change deciles. Cox regression was used to calculate hazard ratios that were adjusted for: social class at recruitment, BMI at age 30, and age group, parity, smoking status, and hormone replacement therapy status in 1995.RESULTS: Women who had been obese at age 30 were more likely to die and significantly more likely to develop cancer in the 6 years after the health survey than non-obese respondents. Women reporting weight gains between age 30 and 1995 were significantly less likely to die during the 6 years after the health survey than those with a stable weight, whereas those with weight loss did not fare any better than those in the stable-weight group.DISCUSSION: Although obesity at young age was associated with subsequent mortality and cancer incidence, weight gain over a time period of 12 to 51 years appeared to be beneficial when compared with women with stable weight over the same time period. Further research is needed to confirm or refute our findings and to allow detailed examination of potential explanations for them.

AB - OBJECTIVE: To investigate the relationship between weight change in adult life and subsequent mortality and cancer incidence in women.RESEARCH METHODS AND PROCEDURES: In 1994 to 1995, all women (age range, 42 to 81) still under general practitioner observation in the United Kingdom's Royal College of General Practitioners Oral Contraception Study (n = 12,303) were sent a health survey asking about health and lifestyle issues, including current weight and weight at age 30. The main outcome measures were 6-year all-cause mortality and cancer incidence among different weight change deciles. Cox regression was used to calculate hazard ratios that were adjusted for: social class at recruitment, BMI at age 30, and age group, parity, smoking status, and hormone replacement therapy status in 1995.RESULTS: Women who had been obese at age 30 were more likely to die and significantly more likely to develop cancer in the 6 years after the health survey than non-obese respondents. Women reporting weight gains between age 30 and 1995 were significantly less likely to die during the 6 years after the health survey than those with a stable weight, whereas those with weight loss did not fare any better than those in the stable-weight group.DISCUSSION: Although obesity at young age was associated with subsequent mortality and cancer incidence, weight gain over a time period of 12 to 51 years appeared to be beneficial when compared with women with stable weight over the same time period. Further research is needed to confirm or refute our findings and to allow detailed examination of potential explanations for them.

U2 - 10.1038/oby.2005.217

DO - 10.1038/oby.2005.217

M3 - Article

C2 - 16286526

VL - 13

SP - 1784

EP - 1792

JO - Obesity Research

JF - Obesity Research

SN - 1930-7381

IS - 10

ER -

Elliott AM, Aucott LS, Hannaford PC, Smith WC. Weight change in adult life and health outcomes. Obesity. 2005 Oct;13(10):1784-1792. https://doi.org/10.1038/oby.2005.217