In Nigeria, the dominant foreign direct investment (FDI) inflows are in the oil and gas sector, which is determined by factor of natural endowment. This study justified that natural resource is the motivation for MNEs internalisation activities in the country. As a result, this research critically examined the role of Resource Seeking Foreign Direct Investments (RSFDIs) in the Niger Delta on Nigeria’s Economic growth. To realise the research objectives, the research examined how RSFDIs are impacting employment generation, infrastructure development, welfare enhancement and economic growth. To obtain conclusions from the research, the researcher sourced and analysed primary and secondary data. Primary data on the research variables, which include RSFDI, Employment, Infrastructure, Welfare and GPD growth were sourced from critical stakeholders in the oil and gas industry in the Niger Delta. While secondary data were sourced from the Central Bank of Nigeria, National Bureau of Statistics and the World Bank. The Ordinary Least Square (multiple) regression techniques were used to estimate the research variables. For the secondary analysis, the findings show that there is a positive relationship between RSFDI and Unemployment. Hence, RSFDI does not contribute positively to the employment generation. There is a positive relationship between RSFDI and Infrastructure, Welfare and GDP. However, all of these relationships are insignificant. For the Primary analysis, the relationship between RSFDI and Unemployment is positive, implying that RSFDI does not promote employment. The relationships between RSFDI and Infrastructure, Welfare and GDP, are positive. However, these relationships are insignificant. The conclusion reached in the research is that RSFDI has not been effective in promoting employment in the Niger Delta. Though it contributes to infrastructure, welfare and GPD, these contributions are not significant to justify investments.